authors |
Sales, I; Abranches, DO; Costa, P; Sintra, TE; Ventura, SPM; Mattedi, S; Coutinho, JAP; Freire, MG; Pinho, SP |
nationality |
International |
journal |
FLUID PHASE EQUILIBRIA |
author keywords |
Artemisinin; hydrotropy; ionic liquids; aqueous solubility; solvatochromic parameters |
keywords |
POLARITY; SOLVENT |
abstract |
Artemisinin is a sesquiterpenoid lactone peroxide, known for its potent antimalarial activity that can be extracted from Artemisia annua L. This compound is only sparingly soluble in water, making its extraction using environmental-friendly and non-toxic aqueous solvents difficult. In the attempt to overcome this limitation, hydrotropes, which are a class of compounds that can assist in increasing the solubility of hydrophobic solutes in water, were investigated in this work. In particular, the hydrotropic capability of ionic liquids (ILs) on the aqueous solubility of artemisinin was studied. The effects of IL concentration and anion nature of 1-butyl-3-methylimidazolium-based ILs on the solubility of artemisinin at 303.2 K in water were evaluated. It is here shown the excellent capacity of ILs containing thiocyanate or dicyanamide anions to enhance the solubility of artemisinin in aqueous media, with a magnitude comparable to that obtained with the best organic solvents. Furthermore, solvatochromic parameters of the ILs aqueous solutions were also measured and combined with COSMO-RS and the cooperative hydrotropy model to establish relations between the artemisinin solubility enhancement and the solvent characteristics. The solubility enhancement of artemisinin is favored by the apolarity of the medium and the lower hydrogen-bond acceptor character of the hydrotrope. (C) 2021 Elsevier B.V. All rights reserved. |
publisher |
ELSEVIER |
issn |
0378-3812 |
isbn |
1879-0224 |
year published |
2021 |
volume |
534 |
digital object identifier (doi) |
10.1016/j.fluid.2021.112961 |
web of science category |
9 |
subject category |
Thermodynamics; Chemistry, Physical; Engineering, Chemical |
unique article identifier |
WOS:000634506700005
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
2.838 |
5 year journal impact factor |
2.454 |
category normalized journal impact factor percentile |
61.717 |
dimensions (citation analysis):
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altmetrics (social interaction):
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