Coordination Compounds As Multi-Delivery Systems for Osteoporosis

authors	Barbosa, JS; Pinto, M; Barreiro, S; Fernandes, C; Mendes, RF; Lavrador, P; Gaspar, VM; Mano, JF; Borges, F; Remiao, F; Braga, SS; Paz, FAA
nationality	International
journal	ACS APPLIED MATERIALS & INTERFACES
author keywords	osteoporosis; bisphosphonates; coordination compounds; controlled release; toxicological safety
keywords	BONE-MINERAL DENSITY; CALCIUM SUPPLEMENTATION; STRONTIUM RANELATE; BISPHOSPHONATE; NANOPARTICLES; EPIDEMIOLOGY; PREVENTION; EFFICACY
abstract	Osteoporosis therapies leveraging bisphosphonates and mineral components (e.g., magnesium, calcium, and strontium) have been raising attention because of their potential for managing this ever-growing disease. The administration of multicomponent therapeutics (combined therapy) in elderly patients is complex and suffers from low patient adherence. Herein, we report an all-in-one combination of four antiosteoporotic components into a new family of coordination complexes: [M-2(H(4)alen)(4)(H2O)(2)]center dot 1.5H(2)O [where M2+ = Mg2+ (1), (Mg0.535Ca0.465)(2+) (2) and (Mg0.505Ca0.450Sr0.045)(2+) (3)]. These solid-state complexes were prepared, for the first time, through microwave-assisted synthesis. It is demonstrated that the compounds are capable of releasing their antiosteoporotic components, both in conditions that mimic the path along the gastrointestinal tract and in long periods under physiological conditions (pH similar to 7.4). More importantly, when administered in low concentrations, the compounds did not elicit a cytotoxic effect toward liver, kidney, and osteoblast-like cell lines. Besides, it is important to highlight the unique coordination complex with four bone therapeutic components, [(Mg0.505Ca0.450Sr0.045)(2)(H(4)alen)(4)(H2O)(2)]center dot 1.5H(2)O (3), which significantly promoted osteoblast metabolic activity up to ca. 1.4-fold versus the control group. These findings bring this type of compounds one-step closer to be considered as an all-in-one and more effective treatment for managing chronic bone diseases, prompting further research on their therapeutic properties.
publisher	AMER CHEMICAL SOC
issn	1944-8244
isbn	1944-8252
year published	2021
volume	13
issue	30
beginning page	35469
ending page	35483
digital object identifier (doi)	10.1021/acsami.1c09121
web of science category	15
subject category	Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
unique article identifier	WOS:000683741400020