Impact of Environmental and Lifestyle Use of Chromium on Male Fertility: Focus on Antioxidant Activity and Oxidative Stress
authors Pereira, SC; Oliveira, PF; Oliveira, SR; Pereira, MD; Alves, MG
nationality International
journal ANTIOXIDANTS
author keywords trivalent chromium; hexavalent chromium; dietary supplements; antioxidants; male germ cells; fertility
keywords LOW-MOLECULAR-WEIGHT; PICOLINATE SUPPLEMENTATION; BODY-COMPOSITION; GLUCOSE-TOLERANCE; HUMAN-SPERMATOZOA; TRANSFERRIN RECEPTORS; TRIVALENT CHROMIUM; SPERM CAPACITATION; DIABETES-MELLITUS; BINDING SUBSTANCE
abstract Male reproductive tissues are strongly susceptible to several environmental and lifestyle stressors. In general, male reproductive health is highly sensitive to oxidative stress, which results in reversible and/or irreversible changes in testosterone-producing cells, spermatogenesis, and sperm quality. Chromium compounds are widely used in the +3 and +6 valence states, as food supplements, and in the industrial field, respectively. Chromium (III) compounds, i.e., Cr(III)-tris-picolinate, [Cr(pic)(3)], known as chromium picolinate, are used as nutritional supplements for the control of diabetes, body weight, and muscular growth. However, previous studies showed that animal models exposed to chromium picolinate experienced degenerative changes in spermatogenesis. Contradictory results are documented in the literature and deserve discussion. Furthermore, the long-term effects of chromium picolinate on the antioxidant system of treated subjects have not been properly studied. Comprehensive studies on the role of this compound will help to establish the safe and useful use of chromium supplementation. On the other hand, chromium (VI) compounds are widely used in several industries, despite being well-known environmental pollutants (i.e., welding fumes). Chromium (VI) is known for its deleterious effects on male reproductive health as toxic, carcinogenic, and mutagenic. Previous studies have demonstrated severe lesions to mouse spermatogenesis after exposure to chromium (VI). However, workers worldwide are still exposed to hexavalent chromium, particularly in electronics and military industries. Data from the literature pinpoints mechanisms of oxidative stress induced by chromium compounds in somatic and germ cells that lead to apoptosis, thus underlining the impairment of fertility potential. In this review, we analyze the benefits and risks of chromium compounds on male fertility, as well as the mechanisms underlying (in)fertility outcomes. Although supplements with antioxidant properties may maximize male fertility, adverse effects need to be investigated and discussed.
publisher MDPI
isbn 2076-3921
year published 2021
volume 10
issue 9
digital object identifier (doi) 10.3390/antiox10091365
web of science category 17
subject category Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology
unique article identifier WOS:000699125100001
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journal analysis (jcr 2019):
journal impact factor 5.014
5 year journal impact factor Not Available
category normalized journal impact factor percentile 87.941
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