Encapsulation of glycosylated porphyrins in silica nanoparticles to enhance the efficacy of cancer photodynamic therapy
| authors | Borzecka, W; Pereira, PMR; Fernandes, R; Trindade, T; Torres, T; Tome, JPC |
| nationality | International |
| journal | MATERIALS ADVANCES |
| keywords | DRUG-DELIVERY; PHOTOPHYSICAL PROPERTIES; SINGLET OXYGEN; PHOTOSENSITIZERS; PHOTOCYTOTOXICITY; NANOCARRIERS; PLATFORMS |
| abstract | In this study, we encapsulated S-galactosylated and S-glucosylated porphyrins (Pors) into amorphous silica nanoparticles (SNPs) to enhance the photodynamic therapy (PDT) activity. The resulting galacto- and gluco-nanoformulations were demonstrated to be spherical in shape with diameters of 197.3 +/- 29.0 nm and 128.3 +/- 22.2 nm. The galacto- and gluco-nanoparticles (NPs) were able to produce a high amount of singlet oxygen (O-1(2)) and were stable under the conditions of the experiments. In vitro studies show that the nanoformulations were effectively taken up by the human bladder cancer cell lines HT-1376 and UM-UC-3. The PDT results show that these photoactive nanoformulations are 3 to 5 times more efficient than the non-encapsulated/free Pors. These Por-silica nanoformulations could be successfully used as novel nanocarriers for the delivery of photosensitizer materials for cancer PDT. |
| publisher | ROYAL SOC CHEMISTRY |
| isbn | 2633-5409 |
| year published | 2021 |
| volume | 2 |
| issue | 5 |
| digital object identifier (doi) | 10.1039/d0ma00830c |
| web of science category | 9 |
| subject category | Materials Science, Multidisciplinary |
| unique article identifier | WOS:000629901500010 |
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