Encapsulation of glycosylated porphyrins in silica nanoparticles to enhance the efficacy of cancer photodynamic therapy
authors Borzecka, W; Pereira, PMR; Fernandes, R; Trindade, T; Torres, T; Tome, JPC
nationality International
journal MATERIALS ADVANCES
keywords DRUG-DELIVERY; PHOTOPHYSICAL PROPERTIES; SINGLET OXYGEN; PHOTOSENSITIZERS; PHOTOCYTOTOXICITY; NANOCARRIERS; PLATFORMS
abstract In this study, we encapsulated S-galactosylated and S-glucosylated porphyrins (Pors) into amorphous silica nanoparticles (SNPs) to enhance the photodynamic therapy (PDT) activity. The resulting galacto- and gluco-nanoformulations were demonstrated to be spherical in shape with diameters of 197.3 +/- 29.0 nm and 128.3 +/- 22.2 nm. The galacto- and gluco-nanoparticles (NPs) were able to produce a high amount of singlet oxygen (O-1(2)) and were stable under the conditions of the experiments. In vitro studies show that the nanoformulations were effectively taken up by the human bladder cancer cell lines HT-1376 and UM-UC-3. The PDT results show that these photoactive nanoformulations are 3 to 5 times more efficient than the non-encapsulated/free Pors. These Por-silica nanoformulations could be successfully used as novel nanocarriers for the delivery of photosensitizer materials for cancer PDT.
publisher ROYAL SOC CHEMISTRY
isbn 2633-5409
year published 2021
volume 2
issue 5
digital object identifier (doi) 10.1039/d0ma00830c
web of science category 9
subject category Materials Science, Multidisciplinary
unique article identifier WOS:000629901500010

Apoio

1suponsers_list_ciceco.jpg