Complex cellular environments imaged by SERS nanoprobes using sugars as an all-in-one vector
authors Gomes, MC; Chen, J; Cunha, A; Trindade, T; Zheng, G; Tome, JPC
nationality International
journal JOURNAL OF MATERIALS CHEMISTRY B
keywords SURFACE-ENHANCED RAMAN; GOLD NANOPARTICLES; RECENT PROGRESS; COLLOIDAL GOLD; TISSUE; CELLS; EXPRESSION; NANOSTRUCTURES; SPECTROSCOPY; GALECTIN-1
abstract Raman spectroscopy coupled with confocal microscopy offers an alternative bioimaging technique overcoming limitations associated with sensitivity, tissue penetration and image resolution. Allied to the surface-enhanced Raman scattering (SERS) properties of gold nanoparticles (AuNP), we designed SERS nanoprobes with enhanced properties and straightforward application as bio-labelling agents for gliomas. The ensuing nanoprobes coated with simple sugar units (galactose or glucose) allowed assessing information about their intracellular localization (vesicular structures), with impressive sensitivity towards complex environments and proved the ability to overcome biological auto-fluorescence and high penetration in tissues. We validate the use of sugars as an all-in-one vector (Raman reporter, conferring high stability, biocompatibility and affinity to glioma cells) as imaging agents using an impressive technique.
publisher ROYAL SOC CHEMISTRY
issn 2050-750X
isbn 2050-7518
year published 2021
volume 9
issue 45
beginning page 9285
ending page 9294
digital object identifier (doi) 10.1039/d1tb01360b
web of science category 11
subject category Materials Science, Biomaterials
unique article identifier WOS:000711999200001
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journal analysis (jcr 2019):
journal impact factor 5.344
5 year journal impact factor 5.022
category normalized journal impact factor percentile 77.632
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