The Emerging Role of Cyclodextrin Metal-Organic Frameworks in Ostheotherapeutics


Metal-Organic Frameworks (MOFs) are a class of coordination compounds with high versatility of design and a high loading ability. These properties have made them increasingly attractive for drug delivery, with research focusing mostly on the preparation of biocompatible MOFs. A suitable strategy is the use of cyclodextrins, cyclic oligosaccharides with excellent biosafety profiles. This review summarises the early steps taken in the application of cyclodextrin-coated and cyclodextrin-based MOFs in the treatment of bone-related diseases divided into three categories: cyclodextrin-coated MOFs, cyclodextrin-based MOFs and cross-linked derivatives of CD-MOFs. Applications in the delivery of bisphosphonates, osteoporotic regulating drugs and non-steroidal anti-inflammatory drugs, for osteoarthritis management, are highlighted. Lastly, the use of these materials in dentistry is exemplified with a recent report.



subject category

Chemistry; Engineering; Materials Science; Physics


Braga, SS; Paz, FAA

our authors


We acknowledge University of Aveiro and FCT/MCTES (Fundacao para a Ciencia e a Tecnologia, Ministerio da Ciencia, da Tecnologia e do Ensino Superior) for financial support to LAQV-REQUIMTE (Ref. UIDB/50006/2020) and to CICECO-Aveiro Institute of Materials (Refs. UIDB/50011/2020 & UIDP/50011/2020) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement.

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