authors |
Oliveira, H; Bednarkiewicz, A; Falk, A; Frohlich, E; Lisjak, D; Prina-Mello, A; Resch, S; Schimpel, C; Vrcek, IV; Wysokinska, E; Gorris, HH |
nationality |
International |
journal |
ADVANCED HEALTHCARE MATERIALS |
author keywords |
bioimaging; efficacy quality and safety (EQS); lanthanides; nanosafety; research development and innovation (R&D&I); safe-by-design; theranostics |
keywords |
PHOTON-UPCONVERTING NANOPARTICLES; TOXICITY ASSESSMENTS; PHOTODYNAMIC THERAPY; NANOMATERIALS; CHALLENGES; EMISSION; PERSPECTIVES; FLUORESCENT; PARTICLES; FLUORIDE |
abstract |
The unique photoluminescent properties of upconversion nanoparticles (UCNPs) have attracted worldwide research interest and inspired many bioanalytical applications. The anti-Stokes emission with long luminescence lifetimes, narrow and multiple absorption and emission bands, and excellent photostability enable background-free and multiplexed detection in deep tissues. So far, however, in vitro and in vivo applications of UCNPs are restricted to the laboratory use due to safety concerns. Possible harmful effects may originate from the chemical composition but also from the small size of UCNPs. Potential end users must rely on well-founded safety data. Thus, a risk to benefit assessment of the envisioned combined therapeutic and diagnostic (theranostic) applications is fundamentally important to bridge the translational gap between laboratory and clinics. The COST Action CM1403 The European Upconversion Network-From the Design of Photon-Upconverting Nanomaterials to Biomedical Applications integrates research on UCNPs ranging from fundamental materials synthesis and research, detection instrumentation, biofunctionalization, and bioassay development to toxicity testing. Such an interdisciplinary approach is necessary for a better and safer theranostic use of UCNPs. Here, the status of nanotoxicity research on UCNPs is compared to other nanomaterials, and routes for the translation of UCNPs into clinical applications are delineated. |
publisher |
WILEY |
issn |
2192-2640 |
isbn |
2192-2659 |
year published |
2019 |
volume |
8 |
issue |
1 |
digital object identifier (doi) |
10.1002/adhm.201801233 |
web of science category |
Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials |
subject category |
Engineering; Science & Technology - Other Topics; Materials Science |
unique article identifier |
WOS:000455779200006
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ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
7.367 |
5 year journal impact factor |
6.964 |
category normalized journal impact factor percentile |
87.158 |
dimensions (citation analysis):
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altmetrics (social interaction):
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