Preparation of hybrid nanocomposite particles for medical practices


This study addresses the preparation of hybrid nanoparticles comprised of magnetite (Fe3O4) cores and a surface functionalized with tetramethylammonium hydroxide (TMAOH). The stabilized core nanoparticles were subsequently coated with a polymer matrix consisting of poly(L-co-D,L lactic acid-co-trimethylene carbonate) and poly (ethylene oxide) - poly(propylene oxide) - poly(ethylene oxide) triblock copolymer. The novel core/shell hybrid nanoparticles combine the concepts of electromagnetic heating by the magnetite cores with the drug storage and release ability of the polymeric shell. These multifunctional hybrid nanoparticles are intended for hyperthermia clinical protocols in local drug delivery and medical practices in oncology. The essential physical features of these hybrid composite nanoparticles were assessed using an array of appropriate advanced characterization techniques. The equivalent average diameters of the composite nanoparticles were relatively uniform and their core/shell mass ratio was estimated through thermogravimetric analysis. The weakening of the intermolecular interactions with decreasing thickness of the coating led to a concomitant decrease in the melting temperature of the shell. The polydispersity index data from dynamic light scattering analysis enabled the conclusion that polymeric species contained in 10 mL of the polymeric matrix solution could effectively coat a maximum of core particles contained in 0.5 mL of ferrofluid.



subject category

Chemistry, Physical


Machado, VD; Andrade, AL; Fabris, JD; Freitas, ETF; Ferreira, JMD; Simon, A; Domingues, RZ; Fernandez-Outon, LE; do Carmo, FA; Souza, ACD; Saba, H



Work supported by the Biomaterials Laboratory, at the Military Institute of Engineering (Brazil) ; Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES) ; the project CICECO, at the Aveiro Institute of Materials (Portugal; grant FCT Ref. UID/CTM/50011/2019) , which is a support by Portuguese national funds through the Science and Technology Foundation (FCT, at the Ministry of Science, Technology and Higher Education) , and also by the Dean's Office for Research, Graduation and Innovation at the Federal Institute of Bahia (PRPGI, at the Federal Institute of Education, Science and Technology of Bahia, in Brazil) , through the funding program 2019/2020 e 2020/2021. The authors also thank the following Brazilian laboratories, for kindly providing technical facilities: Center of Microscopyat UFMG; the Laboratory of Materials and Fuel Cells (LaMPaC, at UFMG) ; Laboratory of Industrial Pharmaceutical Technology (LabTIF, at UFRJ) ; the Biomaterials Lab (at Catholic University SP) ; the Biomaterials Lab at UFOP and the Brazilian Institute of Technology (INT) . JDF is indebted to the Brazilian National Council for the Scientific and Technological Development (CNPq) , for the research grant #304958/20174. ACSS and HS also thank CNPq for the research grants #431990/2018-2 and #313423/20199.

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