abstract
Cationic nanomagnet porphyrin hybrids were synthesized and their photodynamic therapy capabilities were investigated against the Gram (-) Escherichia coli bacteria, the Gram (+) Enterococcus faecalis bacteria and T4-like phage. The synthesis, structural characterization, photophysical properties, and antimicrobial activity of these new materials are discussed. The results show that these new multicharged nanomagnet porphyrin hybrids are very stable in water and highly effective in the photoinactivation of bacteria and phages. Their remarkable antimicrobial activity, associated with their easy recovery, just by applying a magnetic field, makes these materials novel photosensitizers for water or wastewater disinfection.
keywords
MAGNETIC NANOPARTICLES; PHOTODYNAMIC THERAPY; WATER DISINFECTION; WASTE-WATER; PHOTOSENSITIZERS; INACTIVATION; DERIVATIVES; BACTERIA
subject category
Chemistry; Science & Technology - Other Topics; Materials Science
authors
Carvalho, CMB; Alves, E; Costa, L; Tome, JPC; Faustino, MAF; Neves, MGPMS; Tome, AC; Cavaleiro, JAS; Almeida, A; Cunha, A; Lin, Z; Rocha, J
our authors
João Rocha
Full Professor
Zhi Lin
Principal Researcheracknowledgements
We are grateful to the University of Aveiro, Fundacao para a Ciencia e a Tecnologia (FCT) and POCI 2010 (FEDER) for funding the projects POCl/CTM/58183/2004 and PP-DCT/CTM/58183/2004. C. Carvalho, E. Alves and L. Costa are also grateful to FCT for their Ph.D. grants. Thanks are also due to Nuno Micaelo for the preparation of the cover image. This work is dedicated to Prof. Carmen Najera on the occasion of her 60th anniversary.