Magneto-Induced Hyperthermia and Temperature Detection in Single Iron Oxide Core-Silica/Tb3+/Eu3+(Acac) Shell Nano-Objects

abstract

Multifunctional nano-objects containing a magnetic heater and a temperature emissive sensor in the same nanoparticle have recently emerged as promising tools towards personalized nanomedicine permitting hyperthermia-assisted treatment under local temperature control. However, a fine control of nano-systems' morphology permitting the synthesis of a single magnetic core with controlled position of the sensor presents a main challenge. We report here the design of new iron oxide core-silica shell nano-objects containing luminescent Tb3+/Eu3+-(acetylacetonate) moieties covalently anchored to the silica surface, which act as a promising heater/thermometer system. They present a single magnetic core and a controlled thickness of the silica shell, permitting a uniform spatial distribution of the emissive nanothermometer relative to the heat source. These nanoparticles exhibit the Tb3+ and Eu3+ characteristic emissions and suitable magnetic properties that make them efficient as a nanoheater with a Ln(3+)-based emissive self-referencing temperature sensor covalently coupled to it. Heating capacity under an alternating current magnetic field was demonstrated by thermal imaging. This system offers a new strategy permitting a rapid heating of a solution under an applied magnetic field and a local self-referencing temperature sensing with excellent thermal sensitivity (1.64%center dot K-1 (at 40 degrees C)) in the range 25-70 degrees C, good photostability, and reproducibility after several heating cycles.

keywords

ELECTRONIC-ENERGY LEVELS; LANTHANIDE AQUO IONS; NANOPLATFORMS; THERMOMETER; EMISSION; SYSTEM; TUMORS

subject category

Chemistry; Science & Technology - Other Topics; Materials Science; Physics

authors

Nigoghossian, K; Bouvet, B; Felix, G; Sene, S; Costa, L; Milhet, PE; Neto, ANC; Carlos, LD; Oliviero, E; Guari, Y; Larionova, J

Groups

G2 - Photonic, Electronic and Magnetic Materials

Projects

CICECO - Aveiro Institute of Materials (UIDB/50011/2020)

CICECO - Aveiro Institute of Materials (UIDP/50011/2020)

The shape of water: Nanothermometry as a tool to unveil the structure of liquid water and water-based nanofluids (THE SHAPE OF WATER )

Nanoparticles - based 2D thermal bioimaging technologies - NanoTBTech (NanoTBTech)

acknowledgements

J.L., K.N., G.F., L.C., P.-E.M. and Y.G. thank the University of Montpellier and CNRS for financial support, as well as for the project MAGCELL, which was co-financed by the European Union (European Regional Development Fund) as part of the support of interdisciplinary or innovative research projects in S3 fields of the Occitanie region. The work was also developed within the scope of the project CICECO-Aveiro Institute of Materials (UIDB/50011/2020 & UIDP/50011/2020) and The Shape of Water (PTDC/NAN-PRO/3881/2020) financed by Portuguese funds through the FCT/MEC and, when appropriate, co-financed by FEDER under the PT2020 Partnership Agreement. The support of the European Union's Horizon 2020 FET Open program under grant agreement No. 801305 (NanoTBTech) is also acknowledged. Authors are grateful to Platform of Analysis and Characterization (PAC) of ICGM for magnetic and X-ray diffraction measurements and platform MEA for transmission electronic microscopy and STEM-BF/EDX measurements.