Menadione: a platform and a target to valuable compounds synthesis

abstract

Naphthoquinones are important natural or synthetic compounds belonging to the general class of quinones. Many compounds in this class have become drugs that are on the pharmaceutical market for the treatment of various diseases. A special naphthoquinone derivative is menadione, a synthetic naphthoquinone belonging to the vitamin K group. This compound can be synthesized by different methods and it has a broad range of biological and synthetic applications, which will be highlighted in this review.

keywords

DIELS-ALDER REACTIONS; VITAMIN-K DERIVATIVES; CATALYZED REGIOSELECTIVE ALKYLATION; SELECTIVE NEURONAL DIFFERENTIATION; INDUCED OXIDATIVE STRESS; ONE-POT SYNTHESIS; C-H ALKYLATION; ENANTIOSELECTIVE EPOXIDATION; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS

subject category

Chemistry

authors

de Souza, AS; Ribeiro, RCB; Costa, DCS; Pauli, FP; Pinho, DR; de Moraes, MG; da Silva, FD; Forezi, LDM; Ferreira, VF

our authors

acknowledgements

Fellowships granted by CNPq (301873/2019-4 and 306011/2020-4) , CAPES (Financial Code 001) , and FAPERJ (E-26/203.191/2017, E-26/202.800/2017, E-26/010.101106/2018, E-26/200.870/2021, E-26/201.369/2021 and SEI-260003/001178/2020) are gratefully acknowledged.

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