Probing pseudopolymorphic transitions in pharmaceutical solids using Raman spectroscopy: Hydration and dehydration of theophylline
authors Amado, AM; Nolasco, MM; Ribeiro-Claro, PJA
nationality International
journal JOURNAL OF PHARMACEUTICAL SCIENCES
author keywords Raman spectroscopy; hydrates/solvates; hydration/dehydration; water in solids; relative humidity; physical stability; kinetics; intermolecular interactions
keywords NEAR-INFRARED SPECTROSCOPY; BETA-CYCLODEXTRIN DODECAHYDRATE; ANHYDROUS THEOPHYLLINE; STATE REACTIONS; PHYSICAL STABILITY; WATER DIFFUSION; MATRIX TABLETS; VAPOR SORPTION; H/D EXCHANGE; WET MASSES
abstract Theophylline is known to undergo vapor phase induced hydrate-anhydrate pseudopolymorphic transformations, which can affect its bioavailability. In this work, the kinetics of the pseudopolymorphic transitions of theophylline crystals in different storage conditions is studied using a vibrational spectroscopic technique. While the hydration is a single-step process with a half-life time of ca. 5 h, the dehydration occurs through a two-step mechanism. In addition, the phase stability of hydrate-anhydrate systems in different relative humidity (RH) conditions was probed. The critical RH for anhydrous teophylline was found to be at ca. 79%, while the critical RH for dehydration is ca. 30%. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.
publisher JOHN WILEY & SONS INC
issn 0022-3549
year published 2007
volume 96
issue 5
beginning page 1366
ending page 1379
digital object identifier (doi) 10.1002/jps.20923
web of science category Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy; Chemistry
unique article identifier WOS:000246132800034
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