Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases
authors da Silva, MS; Vao, ER; Temtem, M; Mafra, L; Caldeira, J; Aguiar-Ricardo, A; Casimiro, T
nationality International
journal BIOSENSORS & BIOELECTRONICS
author keywords Supercritical fluid technology; Molecular imprinting; MIP; Tryptophan; Enantiomeric separation; HPLC
keywords IMPRINTED POLYMERS; CARBON-DIOXIDE; SEPARATION; CHROMATOGRAPHY; TEMPERATURE; PERFORMANCE; EXTRACTION; ENANTIOMER
abstract Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(N-isopropylacrylamide-co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO(2)), using Boc-L-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of L- and D-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation. (C) 2009 Elsevier B.V. All rights reserved.
publisher ELSEVIER ADVANCED TECHNOLOGY
issn 0956-5663
year published 2010
volume 25
issue 7
beginning page 1742
ending page 1747
digital object identifier (doi) 10.1016/j.bios.2009.12.023
web of science category Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical; Electrochemistry; Nanoscience & Nanotechnology
subject category Biophysics; Biotechnology & Applied Microbiology; Chemistry; Electrochemistry; Science & Technology - Other Topics
unique article identifier WOS:000275978700031
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