Lipophilic composition of Scabiosa stellata L.: an underexploited plant from Batna (Algeria)


Scabiosa stellata L. is the less-studied plant of the species belonging to the genus Scabiosa, but the fact that several Scabiosa species are used in traditional medicine is an incentive to study this species. The profile of the S. stellata hexane extract was established by gas chromatography-mass spectrometry and allowed to conclude that fatty acids and their derivatives (87%) are the major chemical families of this extract. From the identified components, linoleic (19%), palmitic (20%) and linolenic (34%) acids are the major ones. Additionally, triterpenoids, namely beta-sitosterol, stigmasterol, oleanolic and ursolic acids were also found. Simultaneously, the phytochemical study of this extract allowed the isolation and full characterization using 1D and 2D NMR experiments (H-1 and C-13 NMR, HSQC, COSY, HMBC) of interesting metabolites such as 1,3-O-dilinoleoyl-2-O-palmitoyl glycerol and 1-O-linolenoyl-2-O-linoleoyl-3-O-oleoyl glycerol. This first assessment of S. stellata less polar constituents allowed the identification of several important compounds among which, ursolic and stearic acids, 1,3-O-dilinoleoyl-2-O-palmitoyl glycerol and 1-O-linolenoyl-2-O-linoleoyl-3-O-oleoyl glycerol, were found, for the first time in Scabiosa genus. The results reported, index of atherogenicity (AI = 0.55), index of thrombogenicity (TI = 0.23) and the fatty acid ratio (omega-6/omega-3 = 0.55), point out the nutritional value of S. stellata. [GRAPHICS] .






Rahmouni, N; Pinto, DCGA; Santos, SAO; Beghidja, N; Silva, AMS

nossos autores


Thanks are due to the University of Aveiro, to the FCT/MEC and POPH/FSE for the postdoctoral Grant to S. A. O. Santos (SFRH/BPD/84226/2012) and for the financial support of the QOPNA research Unit (FCT UID/QUI/00062/2013) and for CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement and to the Portuguese NMR Network. Thanks are also due to the Algerian MESRS (Ministere de l'Enseignement Superieure et la Recherche Scientifique) via PNE (Programme National Exceptionnel) for financial support, namely the NR displacement.

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