Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels


Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.




Engineering; Materials Science


Kadri, R; Bacharouch, J; Elkhoury, K; Ben Messaoud, G; Kahn, C; Desobry, S; Linder, M; Tamayol, A; Francius, G; Mano, JF; Sanchez-Gonzalez, L; Arab-Tehrany, E

nossos autores


R.K. and J.B. contributed equally to this work. The authors are grateful to the European Commission for the Erasmus Mundus grant to R.K. (Erasmus Mundus External Window 'ELEMENT' Program). The ANRT French agency (project No 312/2012) is also acknowledged for financial support to G.B.M. K.E. acknowledges support from the French Ministry of Higher Education, Research and Innovation. J.M. acknowledges that this work was also developed within the scope of the funded project MARGEL (POCI-01-0145-FEDER-031498) and project CICECO-Aveiro Institute of Materials (POCI-01-0145-FEDER-007679 with Ref. FCT UID/CTM/50011/2013), financed by national funds through the FCT/MEC and, when appropriate, cofinanced by under the Partnership Agreement.

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