Fabrication of Quasi-2D Shape-Tailored Microparticles using Wettability Contrast-Based Platforms
authors Neto, MD; Stoppa, A; Neto, MA; Oliveira, FJ; Gomes, MC; Boccaccini, AR; Levkin, PA; Oliveira, MB; Mano, JF
nationality International
author keywords bioinspired surfaces; oleophobic patterned surfaces; quasi‐ 2D nanostructures; ultrathin microparticles; wettable– dewettable contrast
abstract The ability to fabricate materials with ultrathin architectures enables the breakthrough of low-dimensional structures with high surface area that showcase distinctive properties from their bulk counterparts. They are exploited in a wide range of fields, including energy harvesting, catalysis, and biomedicine. Despite such versatility, the fine tuning of the lateral dimensions and geometry of these structures remains challenging. Prepatterned platforms gain significant attention as enabling technologies to process materials with highly controlled shapes and dimensions. Herein, different nanometer-thick particles of various lateral sizes and geometries (e.g., squares, circles, triangles, hexagons) are processed with high precision and definition, taking advantage of the wettability contrast of oleophilic-oleophobic patterned surfaces. Quasi-2D polymeric microparticles with high shape- and size-fidelity can be retrieved as freestanding objects in a single step. These structures show cell-mediated pliability, and their integration in gravity-enforced human adipose-derived stem cell spheroids leads to an enhanced metabolic activity and a modulated secretion of proangiogenic factors.
issn 0935-9648
isbn 1521-4095
year published 2021
volume 33
issue 14
digital object identifier (doi) 10.1002/adma.202007695
web of science category 7
subject category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
unique article identifier WOS:000623163500001
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 27.398
5 year journal impact factor 26.444
category normalized journal impact factor percentile 97.985
dimensions (citation analysis):
altmetrics (social interaction):