Recent Progress on Polysaccharide-Based Hydrogels for Controlled Delivery of Therapeutic Biomolecules
authors Rial-Hermida, MI; Rey-Rico, A; Blanco-Fernandez, B; Carballo-Pedrares, N; Byrne, EM; Mano, JF
nationality International
journal ACS BIOMATERIALS SCIENCE & ENGINEERING
author keywords biotherapeutics; hydrogels; controlled delivery; polysaccharides; tissue engineering; stimuli-responsiveness
keywords HYALURONIC-ACID HYDROGELS; GROWTH-FACTOR DELIVERY; BONE MORPHOGENETIC PROTEIN-2; BIODEGRADABLE DEXTRAN HYDROGELS; CROSS-LINKED HYDROGELS; CARRAGEENAN-BASED HYDROGELS; IN-VITRO CHARACTERIZATION; CHITOSAN-BASED HYDROGELS; SELF-HEALING HYDROGEL; CONTROLLED-RELEASE
abstract A plethora of applications using polysaccharides have been developed in recent years due to their availability as well as their frequent nontoxicity and biodegradability. These polymers are usually obtained from renewable sources or are byproducts of industrial processes, thus, their use is collaborative in waste management and shows promise for an enhanced sustainable circular economy. Regarding the development of novel delivery systems for biotherapeutics, the potential of polysaccharides is attractive for the previously mentioned properties and also for the possibility of chemical modification of their structures, their ability to form matrixes of diverse architectures and mechanical properties, as well as for their ability to maintain bioactivity following incorporation of the biomolecules into the matrix. Biotherapeutics, such as proteins, growth factors, gene vectors, enzymes, hormones, DNA/RNA, and antibodies are currently in use as major therapeutics in a wide range of pathologies. In the present review, we summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields.
publisher AMER CHEMICAL SOC
issn 2373-9878
year published 2021
volume 7
issue 9
beginning page 4102
ending page 4127
digital object identifier (doi) 10.1021/acsbiomaterials.0c01784
web of science category 26
subject category Materials Science, Biomaterials
unique article identifier WOS:000696370300051
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journal analysis (jcr 2019):
journal impact factor 4.152
5 year journal impact factor 4.619
category normalized journal impact factor percentile 64.474
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