Cork-derived hierarchically porous hydroxyapatite with different stoichiometries for biomedical and environmental applications
authors Scalera, F; Quarta, A; Tobaldi, DM; Pullar, RC; Piccirillo, C
nationality International
journal MATERIALS CHEMISTRY FRONTIERS
keywords CALCIUM-CARBONATE; CERAMICS; ECOCERAMICS; LEAD; ADSORPTION; MORPHOLOGY; PHOSPHATE; REMOVAL; CADMIUM; ENHANCE
abstract Hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)) is the major mineral component of human bone, but has a wide range of interesting and useful properties, and many applications beyond biomedicine. Here we produce HA-based materials from a naturally templated precursor which can have a variety of tailored microstructures and hierarchical porosities, and we investigate their use as designed functional materials for several applications. HA-based materials with different stoichiometries of Ca/P = 1.67 (HA) and 1.5 (Ca-deficient HA) were successfully synthesised from a previously prepared and reported cork-derived CaCO3. The CaCO3 was reacted with a phosphorus containing precursor solution at 60 degrees C, and also successively recalcined at 700 degrees C. The samples prepared at 60 degrees C maintained the 3D honeycomb structure of similar to 20 mu m hexagonal cells typical of cork, and showed high specific surface areas (SSA > 85 m(2) g(-1)) and a high mesoporosity (average mesopores similar to 10-15 nm). These features made them suitable for environmental remediation applications such as heavy metals (i.e. lead) removal from water, with calcium-deficient HA (higher degree of mesoporosity) adsorbing >99% of Pb(ii) ions from solutions containing up to 1.5 g of lead per L. Recalcined samples (SSA = 29 m(2) g(-1)), on the other hand, had very low cytotoxicity towards MG-63 osteoblasts, showing them to be biocompatible for biomaterials. All had cell viabilities of over 70% against a control, and the calcium-deficient HA proved to be even less cytotoxic than the control (>100% viability after 24 and 48 h). Therefore, cork was shown to be an excellent template agent for the design of HA materials with varied properties, tailored for different applications in the environmental and biomedical fields.
publisher ROYAL SOC CHEMISTRY
isbn 2052-1537
year published 2021
volume 5
issue 13
beginning page 5071
ending page 5081
digital object identifier (doi) 10.1039/d1qm00584g
web of science category 11
subject category Chemistry, Multidisciplinary; Materials Science, Multidisciplinary
unique article identifier WOS:000653849000001
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 6.788
5 year journal impact factor 6.79
category normalized journal impact factor percentile 83.749
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg