An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing
authors Vallejo, MCS; Moura, NMM; Faustino, MAF; Almeida, A; Goncalves, I; Serra, VV; Neves, MGPMS
nationality International
journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
author keywords wound healing; photosensitizer; photodynamic process; reactive oxygen species; skin; photobonding
keywords ANTIMICROBIAL PHOTODYNAMIC THERAPY; STAPHYLOCOCCUS-AUREUS; INDOCYANINE GREEN; ANTIBACTERIAL ACTIVITY; RAPID STERILIZATION; HYDROGEL; CANCER; INACTIVATION; MODULATION; MECHANISMS
abstract The concept behind photodynamic therapy (PDT) is being successfully applied in different biomedical contexts such as cancer diseases, inactivation of microorganisms and, more recently, to improve wound healing and tissue regeneration. The effectiveness of PDT in skin treatments is associated with the role of reactive oxygen species (ROS) produced by a photosensitizer (PS), which acts as a double agent. The release of ROS must be high enough to prevent microbial growth and, simultaneously, to accelerate the immune system response by recruiting important regenerative agents to the wound site. The growing interest in this subject is reflected by the increasing number of studies concerning the optimization of relevant experimental parameters for wound healing via PDT, namely, light features, the structure and concentration of the PS, and the wound type and location. Considering the importance of developing PSs with suitable features for this emergent topic concerning skin wound healing, in this review, a special focus on the achievements attained for each PS class, namely, of the non-porphyrinoid type, is given.
publisher MDPI
isbn 1422-0067
year published 2021
volume 22
issue 1
digital object identifier (doi) 10.3390/ijms22010234
web of science category 34
subject category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
unique article identifier WOS:000606253300001
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journal analysis (jcr 2019):
journal impact factor 4.556
5 year journal impact factor 4.653
category normalized journal impact factor percentile 74.208
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