An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing


The concept behind photodynamic therapy (PDT) is being successfully applied in different biomedical contexts such as cancer diseases, inactivation of microorganisms and, more recently, to improve wound healing and tissue regeneration. The effectiveness of PDT in skin treatments is associated with the role of reactive oxygen species (ROS) produced by a photosensitizer (PS), which acts as a double agent. The release of ROS must be high enough to prevent microbial growth and, simultaneously, to accelerate the immune system response by recruiting important regenerative agents to the wound site. The growing interest in this subject is reflected by the increasing number of studies concerning the optimization of relevant experimental parameters for wound healing via PDT, namely, light features, the structure and concentration of the PS, and the wound type and location. Considering the importance of developing PSs with suitable features for this emergent topic concerning skin wound healing, in this review, a special focus on the achievements attained for each PS class, namely, of the non-porphyrinoid type, is given.



subject category

Biochemistry & Molecular Biology; Chemistry, Multidisciplinary


Vallejo, MCS; Moura, NMM; Faustino, MAF; Almeida, A; Goncalves, I; Serra, VV; Neves, MGPMS

our authors


The authors are grateful to the University of Aveiro and Fundacao para a Ciencia e a Tecnologia (FCT) for the financial support of LAQV-REQUIMTE (UIDB/50006/2020), CICECOAveiro Institute of Materials (FCT Ref. UIDB/50011/2020 & UIDP/50011/2020) and CESAM (UIDP/50017/2020+UIDB/50017/2020). Thanks are also due to the projects THERMIC (PTDC/QUICOL/29379/2017) and PREVINE (FCT-PTDC/ASP-PES/29576/2017) for the financial support through national funds and, where applicable, co-financing by the FEDER, within the PT2020 Partnership Agreement, as well as to the Portuguese NMR Network. The research contract of N.M.M. Moura (REF. 048-88-ARH/2018) is funded by national funds (OE), through FCT, in the scope of the framework contract foreseen in Numbers 4, 5 and 6 of Article 23 of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. Additionally, FCT is thanked for the Individual Call to Scientific Employment Stimulus (IG, CEECIND/00430/2017).

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