Magnetic polylactic acid-calcium phosphate-based biocomposite as a potential biomaterial for tissue engineering applications


This work aims the manufacture of injection molded polylactic acid (PLA)-based magnetic biocomposites, presenting an alternative approach to enhance the magnetic susceptibility of PLA-based biocomposites without resorting to the exclusive incorporation of magnetic nanoparticles whose long-term side effects are still unclear. Magnetic biocomposites were obtained by incorporating 5 wt% of iron doped biphasic calcium phosphate (FeBCP) powders into the PLA matrix and compared with similar composites containing 2 and 5 wt% of non-doped BCP powder, as well as neat PLA. The chemical, thermal, mechanical, and magnetic performances were evaluated. Biodegradability according to two sterilization methods used and cytotoxicity were also assessed. The composites with FeBCP exhibited a typical ferromagnetic-like behavior and presented a superior tensile strength even with low concentrations of FeBCP, when compared to PLA or non-doped composites, besides being cytocompatible. The presented proof of concept paves the way for future developments of new magnetic PLA-based biocomposites for biomedical applications.


Tânia S.S. Carvalho; Nilza Ribeiro; Paula M.C. Torres; José C. Almeida; João H. Belo; J.P. Araújo; António Ramos; Mónica Oliveira; Susana M. Olhero

nossos autores


This work is funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT - Portuguese Foundation for Science and Technology under the projects MulBioImplant and 2BBone with references PTDC/EME-EME/32486/2017 and PTDC/CTM-CER/29940/2017, respectively. The project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC) is also acknowledged. P M C Torres and S M Olhero acknowledge FCT for CEECIND/01891/2017 and CEECIND/03393/2017 contracts, respectively. J H Belo thanks FCT for the projects PTDC/FISMAC/31302/2017, PTDC/EME-TED/3099/2020 and CERN/FISTEC/0003/2019 and for his contract DL57/2016 (SFRH-BPD-87430/2012).

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