Magnetic polylactic acid-calcium phosphate-based biocomposite as a potential biomaterial for tissue engineering applications

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abstract

This work aims the manufacture of injection molded polylactic acid (PLA)-based magnetic biocomposites, pre -senting an alternative approach to enhance the magnetic susceptibility of PLA-based biocomposites without resorting to the exclusive incorporation of magnetic nanoparticles whose long-term side effects are still unclear. Magnetic biocomposites were obtained by incorporating 5 wt% of iron doped biphasic calcium phosphate (FeBCP) powders into the PLA matrix and compared with similar composites containing 2 and 5 wt% of non -doped BCP powder, as well as neat PLA. The chemical, thermal, mechanical, and magnetic performances were evaluated. Biodegradability according to two sterilization methods used and cytotoxicity were also assessed. The composites with FeBCP exhibited a typical ferromagnetic-like behavior and presented a superior tensile strength even with low concentrations of FeBCP, when compared to PLA or non-doped composites, besides being cyto-compatible. The presented proof of concept paves the way for future developments of new magnetic PLA-based biocomposites for biomedical applications.

keywords

MECHANICAL-PROPERTIES; POLY(LACTIC ACID); HYPERTHERMIA; COMPOSITES; PLA; BIODEGRADATION; NANOPARTICLES; SCAFFOLDS

subject category

Materials Science

authors

Carvalho, TSS; Ribeiro, N; Torres, PMC; Almeida, JC; Belo, JH; Araujo, JP; Ramos, A; Oliveira, M; Olhero, SM

our authors

foto João Silva

João Silva

Post-Doc Fellowship
foto José Carlos Martins de Almeida

José Carlos Martins de Almeida

Junior Researcher
no photo

Nilza Maria Lopes Ribeiro

Junior Researcher
foto Paula Maria da Costa Torres

Paula Maria da Costa Torres

Assistant Researcher
foto Susana Maria Henriques Olhero

Susana Maria Henriques Olhero

Assistant Professor
foto Tânia Sofia Santos Carvalho

Tânia Sofia Santos Carvalho

PhD Student

Groups

G3 - Electrochemical Materials, Interfaces and Coatings
G5 - Biomimetic, Biological and Living Materials

Projects

Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)

Multifunctional and bio-inspired implant to improve bone integration (MulBioimplant)

Desenvolvimento de biomateriais não sinterizáveis à base de fosfatos de cálcio com bi-funcionalidade: regeneração e tratamento de cancro ósseo (2BBone)

CICECO - Aveiro Institute of Materials (UIDB/50011/2020)

CICECO - Aveiro Institute of Materials (UIDP/50011/2020)

Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)

Demagnetizing-based magnetocaloric refrigeration (MAGCAL)

acknowledgements

This work is funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT-Portuguese Foundation for Science and Technology under the projects MulBioImplant and 2BBone with references PTDC/EME-EME/32486/2017 and PTDC/CTM- CER/29940/2017, respectively. The project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC) is also acknowledged. P M C Torres and S M Olhero acknowledge FCT for CEECIND/01891/2017 and CEECIND/03393/2017 contracts, respec- tively. J H Belo thanks FCT for the projects PTDC/FISMAC/31302/2017, PTDC/EME-TED/3099/2020 and CERN/FISTEC/0003/2019 and for his contract DL57/2016 (SFRH-BPD-87430/2012) .

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Publication Details

type
Journal Article
year
2023
journal
MATERIALS CHEMISTRY AND PHYSICS
volume
296
article number
127175
publisher
ELSEVIER SCIENCE SA
issn
0254-0584
digital object identifier
10.1016/j.matchemphys.2022.127175
web of science article identifier
WOS:000912326800001

Journal Metrics (JCR 2019)

Journal Impact Factor
3.408
Journal Impact Factor (5 yrs)
2.884
category normalized journal percentile
63.535

Citations

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