resumo
Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and the improvements of nanoparticles has been of keen interest in multiple industries, including pharmaceutics, diagnostics, electronics, communications, and cosmetics. In herbal medicines, these nanoparticles have several attractive properties that have brought them to the forefront in searching for novel drug delivery systems by enhancing efficacy, bioavailability, and target specificity. The current review investigated various therapeutic applications of different nano-phytopharmaceuticals in locomotor, dermal, reproductive, and urinary tract disorders to enhance bioavailability and efficacy of phytochemicals and herbal extracts in preclinical and in vitro studies. There is a lack of clinical and extensive preclinical studies. The research in this field is expanding but strong evidence on the efficacy of these nano-phytopharmaceuticals for human use is still limited. The long-term efficacy and safety of nano-phytopharmaceuticals must be ensured with priority before these materials emerge as common human therapeutics. Overall, this review provides up-to-date information on related contemporary research on nano-phytopharmaceuticals and nano-extracts in the fields of dermatological, urogenital, and locomotor disorders.
palavras-chave
URINARY-TRACT-INFECTIONS; OLEIFERA LEAF EXTRACT; DRUG-DELIVERY SYSTEMS; MUCUNA-PRURIENS; SILVER NANOPARTICLES; PARKINSONS-DISEASE; IN-VITRO; ANTIBACTERIAL ACTIVITY; ERECTILE DYSFUNCTION; GOLD NANOPARTICLES
categoria
Plant Sciences
autores
Rajagopal, M; Paul, AK; Lee, MT; Joykin, AR; Por, CS; Mahboob, T; Salibay, CC; Torres, MS; Guiang, MMM; Rahmatullah, M; Jahan, R; Jannat, K; Wilairatana, P; Pereira, MD; Lim, CL; Nissapatorn, V
nossos autores
Projectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
M.d.L.P. thanksProjectCICECO-AveiroInstituteofMaterials, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020, financed by national funds through the FCT/MEC (PIDDAC).