resumo
Improving the aqueous solubility of poorly soluble hydrophobiccompounds is a topic of great interest to the pharmaceutical, chemical,and food industries. The poor solubility of these compounds in waterposes a challenge in developing sustainable processes for their extraction,separation, and formulation. Therefore, in this study, the use ashydrotropes of biobased solvents such as & gamma;-valerolactone (GVL),Cyrene, ethyl lactate, and alkanediols (1,2-propanediol, 1,5-pentanediol,and 1,6-hexanediol) to improve the solubility of two model compounds(syringic acid and ferulic acid) in water is investigated. The effectsof the concentration and structure of biobased solvents on the solubilityof phenolic compounds in aqueous solutions at (303.2 & PLUSMN; 0.5) Kwere studied. The results showed that the aqueous solubility of thephenolic compounds studied typically increased with the log (K (OW)) of the hydrotrope (1,2-propanediol
palavras-chave
DRUG SOLUBILIZATION; GAMMA-VALEROLACTONE; WATER; ACID
categoria
Engineering
autores
Silva, SS; Abranches, DO; Pinto, AS; Soares, BP; Passos, H; Ferreira, AM; Coutinho, JAP
nossos autores
Ana Maria da Conceição Ferreira Takahashi
Investigador Júnior
Dinis O. Abranches
Investigador Auxiliar
Helena Isabel Sousa Passos
Investigador Júnior
Sandra Pereira Magina
InvestigadorGrupos
G4 - Materiais Renováveis e Economia Circular
G6 - Materiais Virtuais e Inteligência Artificial
Projectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
This work was partly developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC). H.P. and A.M.F. thank the FCT for contracts CEECIND/00831/2017 and CEECIND/00361/2022, respectively, under the Scientific Stimulus-Individual Call.