Solubility Enhancement of Hydrophobic Compounds in Aqueous Solutions Using Biobased Solvents as Hydrotropes

abstract

Improving the aqueous solubility of poorly soluble hydrophobiccompounds is a topic of great interest to the pharmaceutical, chemical,and food industries. The poor solubility of these compounds in waterposes a challenge in developing sustainable processes for their extraction,separation, and formulation. Therefore, in this study, the use ashydrotropes of biobased solvents such as & gamma;-valerolactone (GVL),Cyrene, ethyl lactate, and alkanediols (1,2-propanediol, 1,5-pentanediol,and 1,6-hexanediol) to improve the solubility of two model compounds(syringic acid and ferulic acid) in water is investigated. The effectsof the concentration and structure of biobased solvents on the solubilityof phenolic compounds in aqueous solutions at (303.2 & PLUSMN; 0.5) Kwere studied. The results showed that the aqueous solubility of thephenolic compounds studied typically increased with the log (K (OW)) of the hydrotrope (1,2-propanediol

keywords

DRUG SOLUBILIZATION; GAMMA-VALEROLACTONE; WATER; ACID

subject category

Engineering

authors

Silva, SS; Abranches, DO; Pinto, AS; Soares, BP; Passos, H; Ferreira, AM; Coutinho, JAP

our authors

acknowledgements

This work was partly developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC). H.P. and A.M.F. thank the FCT for contracts CEECIND/00831/2017 and CEECIND/00361/2022, respectively, under the Scientific Stimulus-Individual Call.

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