resumo
Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans' exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic-inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.
palavras-chave
POLYELECTROLYTE MULTILAYER FILMS; CATIONIC BIPOLAR AMPHIPHILES; SELECTIVE N-ACYLATION; SELF-ASSEMBLY PROCESS; BY-LAYER TECHNIQUE; CROSS-LINKING; COMPARTMENTALIZED CAPSULES; HYDROPHOBIC DERIVATIVES; CONSECUTIVE ADSORPTION; FACILE PREPARATION
categoria
Pharmacology & Pharmacy
autores
Petroni, S; Tagliaro, I; Antonini, C; D'Arienzo, M; Orsini, SF; Mano, JF; Brancato, V; Borges, J; Cipolla, L
nossos autores
João Borges
Investigador Auxiliar
João Mano
Vice-DiretorProjectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
J.F.M. and J.B. acknowledge financial support by the Programa Operacional Regional do Centro-Centro 2020, in the component FEDER, and by national funds (OE) through Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT/MCTES), in the scope of the project "SUPRASORT" (PTDC/QUI-OUT/30658/2017, CENTRO-01-0145-FEDER-030658). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 and LA/P/0006/2020, financed by national funds through the FCT/MEC (PIDDAC). J.B. gratefully acknowledges FCT for the individual Assistant Researcher contract (2020.00758.CEECIND) under the Scientific Employment Stimulus-Individual Call. S.P., S.F.O., M.D. and L.C. gratefully thank the Cariplo Foundation with respect to the BIOSTAR-PACK project (2020-0993) for financial support.