resumo
The complex [Ru([9]aneS(3))phenCl]Cl (phen = 1,10-phenanthroline) and its synthetic precursor [Ru([9]aneS(3))dmsoCl(2)] were immobilized in permethylated beta-cyclodextrin (TRIMEB). A new crystalline structure of the precursor, obtained from a batch ethanol solution at low temperature (4A degrees C), is fully described from single-crystal X-ray diffraction data. [Ru([9]aneS(3))phenCl]Cl was also encapsulated in native beta-cyclodextrin for comparison with the TRIMEB compound. All three compounds were obtained with a 1:1 host:guest stoichiometry and were studied by powder X-ray diffraction (including synchrotron radiation data), thermogravimetric analysis (TGA), (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The bacterial growth inhibitory action of the complex [Ru([9]aneS(3))phenCl]Cl and its two cyclodextrin compounds was tested on Gram-negative (Salmonella, Escherichia) and Gram-positive strains (Bacillus, Listeria, Enterococcus and Staphilococcus) and results show a positive effect of cyclodextrin immobilization on the antimicrobial properties.
palavras-chave
PERMETHYLATED BETA-CYCLODEXTRIN; MOLYBDENOCENE DICHLORIDE CP2MOCL2; METAL-CARBONYL-COMPLEXES; C-13 CHEMICAL-SHIFTS; INCLUSION-COMPOUNDS; POLYPYRIDYL COMPLEXES; HIGH-RESOLUTION; ANTICANCER; CHEMISTRY; DIFFRACTION
categoria
Biochemistry & Molecular Biology
autores
Marques, J; Braga, TM; Paz, FAA; Santos, TM; Lopes, MDS; Braga, SS
nossos autores
Filipe Alexandre Almeida Paz
Investigador Principal
Susana Isabel Fonseca de Almeida Santos Braga
Investigador
Teresa Margarida dos Santos
Professor(a) Jubilado(a)agradecimentos
We wish to acknowledge professor Jacek Klinowski. J. Marques acknowledges FCT and FEDER (Project PDTC/SAU/BEB-66896/2006) for her research grant. We also wish to thank FCT for the financial support towards the purchase of the single-crystal diffractometer. The ESRF (Grenoble, France) is also acknowledged for the invitation and access to their synchrotron radiation research facilities, in particular the beam lines BM01a and ID31.