|
authors |
Marques, J; Braga, TM; Paz, FAA; Santos, TM; Lopes, MDS; Braga, SS |
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nationality |
International |
|
journal |
BIOMETALS |
|
author keywords |
Ruthenium(II) complexes; Phenanthroline; beta-CD; TRIMEB; Antimicrobial activity |
|
keywords |
PERMETHYLATED BETA-CYCLODEXTRIN; MOLYBDENOCENE DICHLORIDE CP2MOCL2; METAL-CARBONYL-COMPLEXES; C-13 CHEMICAL-SHIFTS; INCLUSION-COMPOUNDS; POLYPYRIDYL COMPLEXES; HIGH-RESOLUTION; ANTICANCER; CHEMISTRY; DIFFRACTION |
|
abstract |
The complex [Ru([9]aneS(3))phenCl]Cl (phen = 1,10-phenanthroline) and its synthetic precursor [Ru([9]aneS(3))dmsoCl(2)] were immobilized in permethylated beta-cyclodextrin (TRIMEB). A new crystalline structure of the precursor, obtained from a batch ethanol solution at low temperature (4A degrees C), is fully described from single-crystal X-ray diffraction data. [Ru([9]aneS(3))phenCl]Cl was also encapsulated in native beta-cyclodextrin for comparison with the TRIMEB compound. All three compounds were obtained with a 1:1 host:guest stoichiometry and were studied by powder X-ray diffraction (including synchrotron radiation data), thermogravimetric analysis (TGA), (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The bacterial growth inhibitory action of the complex [Ru([9]aneS(3))phenCl]Cl and its two cyclodextrin compounds was tested on Gram-negative (Salmonella, Escherichia) and Gram-positive strains (Bacillus, Listeria, Enterococcus and Staphilococcus) and results show a positive effect of cyclodextrin immobilization on the antimicrobial properties. |
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publisher |
SPRINGER |
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issn |
0966-0844 |
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year published |
2009 |
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volume |
22 |
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issue |
3 |
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beginning page |
541 |
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ending page |
556 |
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digital object identifier (doi) |
10.1007/s10534-009-9211-x |
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web of science category |
Biochemistry & Molecular Biology |
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subject category |
Biochemistry & Molecular Biology |
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unique article identifier |
WOS:000266074400014
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