Cyclodextrins improve the antimicrobial activity of the chloride salt of Ruthenium(II) chloro-phenanthroline-trithiacyclononane
authors Marques, J; Braga, TM; Paz, FAA; Santos, TM; Lopes, MDS; Braga, SS
nationality International
journal BIOMETALS
author keywords Ruthenium(II) complexes; Phenanthroline; beta-CD; TRIMEB; Antimicrobial activity
keywords PERMETHYLATED BETA-CYCLODEXTRIN; MOLYBDENOCENE DICHLORIDE CP2MOCL2; METAL-CARBONYL-COMPLEXES; C-13 CHEMICAL-SHIFTS; INCLUSION-COMPOUNDS; POLYPYRIDYL COMPLEXES; HIGH-RESOLUTION; ANTICANCER; CHEMISTRY; DIFFRACTION
abstract The complex [Ru([9]aneS(3))phenCl]Cl (phen = 1,10-phenanthroline) and its synthetic precursor [Ru([9]aneS(3))dmsoCl(2)] were immobilized in permethylated beta-cyclodextrin (TRIMEB). A new crystalline structure of the precursor, obtained from a batch ethanol solution at low temperature (4A degrees C), is fully described from single-crystal X-ray diffraction data. [Ru([9]aneS(3))phenCl]Cl was also encapsulated in native beta-cyclodextrin for comparison with the TRIMEB compound. All three compounds were obtained with a 1:1 host:guest stoichiometry and were studied by powder X-ray diffraction (including synchrotron radiation data), thermogravimetric analysis (TGA), (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The bacterial growth inhibitory action of the complex [Ru([9]aneS(3))phenCl]Cl and its two cyclodextrin compounds was tested on Gram-negative (Salmonella, Escherichia) and Gram-positive strains (Bacillus, Listeria, Enterococcus and Staphilococcus) and results show a positive effect of cyclodextrin immobilization on the antimicrobial properties.
publisher SPRINGER
issn 0966-0844
year published 2009
volume 22
issue 3
beginning page 541
ending page 556
digital object identifier (doi) 10.1007/s10534-009-9211-x
web of science category Biochemistry & Molecular Biology
subject category Biochemistry & Molecular Biology
unique article identifier WOS:000266074400014
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journal impact factor 2.479
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