Silicate and borate glasses as composite fillers: a bioactivity and biocompatibility study
authors Lopes, PP; Ferreira, BJML; Gomes, PS; Correia, RN; Fernandes, MH; Fernandes, MHV
nationality International
journal JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
keywords IN-VITRO BIOACTIVITY; SOL-GEL GLASSES; BONE CELL-CULTURES; OSTEOBLASTIC DIFFERENTIATION; MECHANICAL-PROPERTIES; PHOSPHATE; HYDROXYAPATITE; PROLIFERATION; APATITE; GROWTH
abstract Composites filled with a silicate glass (CSi) and a new borate glass (CB) were developed and compared in terms of their in vitro behaviour both in acellular and cellular media. Acellular tests were carried out in SBF and the composites were characterized by SEM-EDS, XRD and ICP. Biocompatibility studies were investigated by in vitro cell culture with MG-63 osteoblast-like and human bone marrow cells. The growth of spherical calcium phosphate aggregates was observed in acellular medium on all composite surfaces indicating that these materials became potentially bioactive. The biological assessment resulted in a dissimilar behavior of the composites. The CSi demonstrated an inductive effect on the proliferation of cells. The cells showed a normal morphology and high growth rate when compared to standard culture plates. Contrarily, inhibition of cell proliferation occurred in the CB probably due to its high degradation rate, leading to high B and Mg ionic concentration in the cell culture medium.
publisher SPRINGER
issn 0957-4530
year published 2011
volume 22
issue 6
beginning page 1501
ending page 1510
digital object identifier (doi) 10.1007/s10856-011-4331-6
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000291702500014
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journal impact factor 2.489
5 year journal impact factor 2.832
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