Mariana Coutinho Sardo

Assistant Researcher

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Department

  • Chemistry
  • 15.3.20

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Short CV

2016 - 2018: post-doctoral fellow at CICECO - Aveiro Institute of Materials under the supervision of Doctor Luis Mafra and Professor João Rocha;

2010 - 2016: post-doctoral fellow at CICECO - Aveiro Institute of Materials and Laboratorium für Physikalische Chemie, ETH Zürich supervised by Doctor Luis Mafra, Professor João Rocha and Professor Beat H. Meier; 

2009: PhD in Physical Chemistry: " Weak intermolecular interactions in advanced functional materials: spectroscopic and computational studies” (supervision of Prof. Paulo Ribeiro-Claro), Chemistry Department, University of Aveiro. During this period, 5 months were spent in the University of Malaga, Spain, working in the group of Professor Juan Carlos Otero, developing SERS studies on pharmaceutical compounds;

2005: Degree in Physics and Chemistry (for teaching), Univ. Aveiro (17/20) 

SCIENTIFIC INTERESTS 

- Combining high-resolution solid-state NMR methods, X-ray diffraction and computational approaches to study crystal packing interactions in small molecules (namely pharmaceuticals) and materials - NMR crystallography; 

- Study drug-drug and drug-host interactions of molecular scaffolds as drug delivery systems. 

- NMR characterization of modified nanoporous solid sorbents with potential for gas capture (by using 13C-labelled CO2 in a gas mixture); 

- NMR characterization of porous materials relevant in heterogeneous catalysis (study of Lewis and Brønsted acidity);

OTHER INTERESTS 

- Responsible for preparing and delivering solid-state NMR Hands-on courses (II Jornadas Nacionais de Caracterização de Materiais - 2017 and IV Ibero-American NMR Meeting - 2012). - Co-President of the Young Chemists Group (GQJ) of the Portuguese Chemical Society (SPQ) between 2010-2012 - Member of the organizing committee of several scientific events: Chemistry Olympics competitions, the Portuguese Physics students meeting (2004), International conference on solubility phenomena (2004), Young Portuguese Chemists meeting (2010), European Young Chemists Network (EYCN) delegates assembly (2012) and EYCN contribution to the 4EuCheMS (2012), IV Ibero-American NMR Meeting (2012).

Scientific Interests

- NMR characterization of modified nanoporous solid sorbents with potential for gas capture (by using 13C-labelled CO2 in a gas mixture);

- NMR characterization of porous materials relevant in heterogeneous catalysis (study of Lewis and Brønsted acidity);

- Combining high-resolution solid-state NMR methods, X-ray diffraction and computational approaches to study crystal packing interactions in small molecules (namely pharmaceuticals) and materials

- NMR crystallography;

- Study drug-drug and drug-host interactions of molecular scaffolds as drug delivery systems.

Present Research Group

Dr. Luis Miguel Monteiro Mafra; Professor João Rocha; Dr. Ildefonso Marin; Dr. Marina Ilkaeva, Dr. Ricardo Vieira, Dra. Paula Soares Santos; Carlos Bornes; João Pereira

Main present collaborators

Professor Beat H. Meier (ETH - Zurich); Prof. José M. Ferreira (UA); Dr. José R.B. Gomes (UA); Prof. Isabel Neves (U. Minho); Dr. Paula Ferreira (UA); Prof. Teresa Duarte (IST); Prof. Moisés Pinto (IST); Prof. Norberto Masciocchi (U. Insubria)

Selected Publications

1. "Comparison of different silica microporous structures as drug delivery systems for in vitro models of solid tumors", Natália Vilaça, Ana F. Machado, Filipa Morais-Santos, Ricardo Amorim, A. Patrícia Neto, Enora Logodin, Manuel F. R. Pereira, Mariana Sardo, João Rocha, Pier Parpot, António M. Fonseca, Fátima Baltazar and Isabel C. Neves, RSC Adv., 2017, 7, 13104-13111.

2. "PAIN with and without PAR: Variants for third-spin assisted heteronuclear polarization transfer", Vipin Agarwal*, Mariana Sardo*, Ingo Scholz, Anja Böckmann, Matthias Ernst and Beat H. Meier, J. Biomol. NMR 2013, 56(4), 365-377. (*authors equally contributed for this work)

 3. "Combining multinuclear high-resolution solid-state MAS NMR and computational methods for resonance assignment of glutathione tripeptide", Mariana Sardo, Renée Siegel, Sérgio M. Santos, João Rocha, José R. B. Gomes, Luis Mafra, J. Phys. Chem. A 2012, 116 (25), 6711–6719.

4. "3D–2D–0D Stepwise Deconstruction of a Water Framework Templated by a Nanoporous Organic–Inorganic Hybrid Host", João Rocha, Fa-Nian Shi, Filipe A. Almeida Paz, Luis Mafra, Mariana Sardo, Luis Cunha-Silva, James Chisholm, Paulo Ribeiro-Claro and Tito Trindade, Chem. Eur. J. 2010, 16, 7741-7749.

Ongoing Supervisions

Ana Teresa Abreu Poças

MSc Student

Andrea Chacón Calderón

PhD Student

Daniel António Cunha Pereira

PhD Student

Márcio Miguel da Silva Soares

PhD Student

Pedro Ouro

PhD Student

Projects

Publications

Microwave-assisted N,N-dialkylation of amine-functionalized periodic mesoporous phenylene-silica: An easy and fast way to design materials

Lourenco, MAO; Ferreira, MJG; Sardo, M; Mafra, L; Gomes, JRB; Ferreira, P
2017, MICROPOROUS AND MESOPOROUS MATERIALS, 249, 10-15.
ISBN: 1873-3093

Comparison of different silica microporous structures as drug delivery systems for in vitro models of solid tumors

Vilaca, N; Machado, AF; Morais-Santos, F; Amorim, R; Neto, AP; Logodin, E; Pereira, MFR; Sardo, M; Rocha, J; Parpot, P; Fonseca, AM; Baltazar, F; Neves, IC
2017, RSC ADVANCES, 7, 22, 13104-13111.

Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X-ray and Solid-State NMR

Martins, ICB; Sardo, M; Santos, SM; Femandes, A; Antunes, A; Andre, V; Mafra, L; Duarte, MT
2016, CRYSTAL GROWTH & DESIGN, 16, 1, 154-166.

Interaction of CO2 and CH4 with Functionalized Periodic Mesoporous Phenylene-Silica: Periodic DFT Calculations and Gas Adsorption Measurements

Lourenco, MAO; Siquet, C; Sardo, M; Mafra, L; Pires, J; Jorge, M; Pinto, ML; Ferreira, P; Gomes, JRB
2016, JOURNAL OF PHYSICAL CHEMISTRY C, 120, 7, 3863-3875.

Diazole-based powdered cocrystal featuring a helical hydrogen-bonded network: Structure determination from PXRD, solid-state NMR and computer modeling

Sardo, M; Santos, SM; Babaryk, AA; Lopez, C; Alkorta, I; Elguero, J; Claramunt, RM; Mafra, L
2015, SOLID STATE NUCLEAR MAGNETIC RESONANCE, 65, 49-63.

X-ray and NMR Crystallography Studies of Novel Theophylline Cocrystals Prepared by Liquid Assisted Grinding

Fernandes, JA; Sardo, M; Mafra, L; Choquesillo-Lazarte, D; Masciocchi, N
2015, CRYSTAL GROWTH & DESIGN, 15, 8, 3674-3683.

Micro- and Mesoporous Structures as Drug Delivery Carriers for Salicylic Acid

Vilaca, N; Morais-Santos, F; Machado, AF; Sirkecioglu, A; Pereira, MFR; Sardo, M; Rocha, J; Parpot, P; Fonseca, AM; Batazar, F; Neves, IC
2015, JOURNAL OF PHYSICAL CHEMISTRY C, 119, 7, 3589-3595.

Catalytic dehydration of fructose to HMF over sulfonic acid functionalized periodic mesoporous organosilicas: role of the acid density

Bispo, C; Vigier, KD; Sardo, M; Bion, N; Mafra, L; Ferreira, P; Jerome, F
2014, CATALYSIS SCIENCE & TECHNOLOGY, 4, 8, 2235-2240.

Monitoring hydration in lime-metakaolin composites using electrochemical impedance spectroscopy and nuclear magnetic resonance spectroscopy

Pesce, GL; Bowen, CR; Rocha, J; Sardo, M; Allen, GC; Walker, PJ; Denuault, G; Serrapede, M; Ball, RJ
2014, CLAY MINERALS, 49, 3, 341-358.

Thermal and mechanical stability of lanthanide-containing glass-ceramic sealants for solid oxide fuel cells

Reddy, AA; Goel, A; Tulyaganov, DU; Sardo, M; Mafra, L; Pascual, MJ; Kharton, VV; Tsipis, EV; Kolotygin, VA; Ferreira, JMF
2014, JOURNAL OF MATERIALS CHEMISTRY A, 2, 6, 1834-1846.

Characterisation of pharmaceutical solids combining NMR, X-ray diffraction and computer modelling

In María Angeles Canales (Eds.), Biophysical Techniques in Drug Discovery
Mariana Sardo, Inês Martins, Chiara Vladiskovic, M.Teresa Duarte, João Rocha, Norberto Masciocchi and Luís Mafra
2018, 120-169, Royal Society of Chemistry.
ISBN: 978-1-78262-733-3

Calculation of NMR tensors: application to small molecule pharmaceutics

In Yuriy A. Abramov (Eds.), Computational Approaches in Pharmaceutical Solid State Chemistry
Luis Mafra, Sérgio Santos, Mariana Sardo, Heather Schmidt
2016, 287-329, John Wiley & Sons, Inc..
ISBN: 9781118700686

Solid-state NMR applications in the structural elucidation of small molecules

In Maria-Magdalena Cid, Jorge Bravo (Eds.), Structure Elucidation in Organic Chemistry : The Search for the Right Tools
Mariana Sardo, João Rocha and Luís Mafra
2014, 173-240, Wiley-VCH Verlag GmbH & Co. KGaA.
ISBN: 9783527664610

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