INGested nanomaterials and metal MIXtures in food: developing integrated strategies to support human health risk assessment and regulatory frameworks


MOTIVATION: Dietary exposure has been considered part of the exposome, therefore food safety is essential for individual and public health. Unquestionably, it is necessary to assure that preventive mechanisms are available to the scientific community and regulators, that rapidly respond to emergent needs of  safety assurance of, for example, the use of nanotechnology in the food industry.BACKGROUND: Nanotechnology has many applications in the food industry, including improvement of organoleptic properties, extended shelf-life, or nutritional value. Yet, there is growing concern about the potential adverse health effects resulting from the use of engineered nanomaterials (ENM) as food additives. Evidence of toxicity associated with ingested ENM continues to grow, but several critical knowledge gaps exist, preventing regulators and industry from assessing the potential health risks. These knowledge gaps include: 1) uncertain human exposure data; 2) lack of understanding of physicochemical ENM transformations within complex food matrices and within the gastrointestinal tract and their effect on bioavailability and toxicity; and 3) lack of validated, standardized methodologies dedicated to risk assessment a????er exposure by oral pathway to these xenobiotics.

Main Local Researcher

Cláudia Batista Lopes


Universidade do Porto - Instituto de Saúde Pública da Universidade do Porto


Universidade de Aveiro


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