N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents

abstract

A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.

keywords

VISCERAL LEISHMANIASIS; DIAGNOSIS; DRUGS

subject category

Microbiology; Pharmacology & Pharmacy

authors

Vale-Costa, S; Costa-Gouveia, J; Perez, B; Silva, T; Teixeira, C; Gomes, P; Gomes, MS

our authors

Groups

acknowledgements

This research work was mainly supported by FEDER funds through

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