authors |
Shi, FN; Almeida, JC; Helguero, LA; Fernandes, MHV; Knowles, JC; Rocha, J |
nationality |
International |
journal |
INORGANIC CHEMISTRY |
keywords |
OCTACALCIUM PHOSPHATE; PROTON CONDUCTIVITY; APATITE-FORMATION; VITAMIN-D; BISPHOSPHONATES; BIOACTIVITY; MECHANISM; HEALTH; MILK |
abstract |
Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)(3)(HPXBP)] (CaP1) and [Ca-2(H2O)(2)(HPXBP)(1.5)] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P (1) over bar space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis. |
publisher |
AMER CHEMICAL SOC |
issn |
0020-1669 |
year published |
2015 |
volume |
54 |
issue |
20 |
beginning page |
9929 |
ending page |
9935 |
digital object identifier (doi) |
10.1021/acs.inorgchem.5b01634 |
web of science category |
Chemistry, Inorganic & Nuclear |
subject category |
Chemistry |
unique article identifier |
WOS:000363224000034
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
4.825 |
5 year journal impact factor |
4.501 |
category normalized journal impact factor percentile |
92.222 |
dimensions (citation analysis):
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altmetrics (social interaction):
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