Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders

authors	Shi, FN; Almeida, JC; Helguero, LA; Fernandes, MHV; Knowles, JC; Rocha, J
nationality	International
journal	INORGANIC CHEMISTRY
keywords	OCTACALCIUM PHOSPHATE; PROTON CONDUCTIVITY; APATITE-FORMATION; VITAMIN-D; BISPHOSPHONATES; BIOACTIVITY; MECHANISM; HEALTH; MILK
abstract	Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)(3)(HPXBP)] (CaP1) and [Ca-2(H2O)(2)(HPXBP)(1.5)] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P (1) over bar space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis.
publisher	AMER CHEMICAL SOC
issn	0020-1669
year published	2015
volume	54
issue	20
beginning page	9929
ending page	9935
digital object identifier (doi)	10.1021/acs.inorgchem.5b01634
web of science category	Chemistry, Inorganic & Nuclear
subject category	Chemistry
unique article identifier	WOS:000363224000034