Rhodamine derived colorimetric and fluorescence mercury(II) chemodosimeter for human breast cancer cell (MCF7) imaging

abstract

Condensation of rhodaminehydrazone with naphthalene-1-carboxaldehyde generates a colourless probe, RDHDNAP that can selectively detect Hg2+ through generation of a pink color along with significant fluorescence enhancement. The binding constant and lowest detection limit for Hg2+ are 2.0 x 10(5) M-1 and 3 x 10(-7) M respectively. Hg2+ imaging in human breast cancer cells (MCF7) under a fluorescence microscope is achieved.

keywords

RESONANCE ENERGY-TRANSFER; LIVING CELLS; HG2+ IONS; RATIOMETRIC SENSOR; CU-II; CHEMOSENSORS; PROBE; EMISSION; BINDING; DESIGN

subject category

Chemistry

authors

Kumari, B; Lohar, S; Adhikari, S; Sengupta, A; Chattopadhyay, A; Brandao, P; Felix, V; Das, D

our authors

acknowledgements

Authors sincerely thank UGC-DAE-CRS-Kolkata for financial support. B. Kumari sincerely thanks BU for fellowship. S. Lohar is thankful to CSIR for fellowship. Authors sincerely acknowledge CAS (B. U.) for assistance. Suggestions from reviewers to improve the quality of the MS are gratefully acknowledged.

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