Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic-Hydrophilic Micropatterns

abstract

High-throughput fabrication of freestanding hydrogel particles with defined geometry and size for 3D cell culture, cell screenings, and modular tissue engineering is reported. The method employs discontinuous dewetting using superhydrophobic-hydrophilic micropatterns.

keywords

HIGH-THROUGHPUT; MAGNETIC NANOPARTICLES; MICROSCALE HYDROGELS; FLOW LITHOGRAPHY; MICROPARTICLES; BIOMATERIALS; ARRAYS; ALGINATE; PLATFORM; TRENDS

subject category

Chemistry; Science & Technology - Other Topics; Materials Science; Physics

authors

Neto, AI; Demir, K; Popova, AA; Oliveira, MB; Mano, JF; Levkin, PA

our authors

acknowledgements

The authors acknowledge financial support from the FCT-Fundacao para a Ciencia e para a Tecnologia through a Ph.D. grant with the reference SFRH/BD/73119/2010. This work was funded by the Helmholtz Association's Initiative and Networking Fund (Grant No. VH-NG-621) and European Research Council Starting Grant (ERC-2013-StG 337077 DropCellArray). The authors are grateful to Dr. Christian Greiner's group of (KIT) for their help with optical profilometry measurements and to Dr. Gary Davidson and Dr. Olivier Kassel (Institute of Toxicology and Genetics, KIT) for providing the cell lines.

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