Industrial potential of lipoxygenases
authors Heshof, R; de Graaff, LH; Villaverde, JJ; Silvestre, AJD; Haarmann, T; Dalsgaard, TK; Buchert, J
nationality International
journal CRITICAL REVIEWS IN BIOTECHNOLOGY
author keywords Application; bleaching; hydroperoxide; lipoxygenase; oleochemistry; oxylipin; unsaturated fatty acid
keywords PARASITICA VAR. NICOTIANAE; UNSATURATED FATTY-ACIDS; SOYBEAN LIPOXYGENASE; PSEUDOMONAS-AERUGINOSA; MANGANESE LIPOXYGENASE; MINI-LIPOXYGENASE; CRYSTAL-STRUCTURE; LINOLEIC-ACID; WHEAT-FLOUR; MAMMALIAN 15-LIPOXYGENASE
abstract Lipoxygenases (LOXs) are iron- or manganese-containing oxidative enzymes found in plants, animals, bacteria and fungi. LOXs catalyze the oxidation of polyunsaturated fatty acids to the corresponding highly reactive hydroperoxides. Production of hydroperoxides by LOX can be exploited in different applications such as in bleaching of colored components, modification of lipids originating from different raw materials, production of lipid derived chemicals and production of aroma compounds. Most application research has been carried out using soybean LOX, but currently the use of microbial LOXs has also been reported. Development of LOX composition with high activity by heterologous expression in suitable production hosts would enable full exploitation of the potential of LOX derived reactions in different applications. Here, we review the biological role of LOXs, their heterologous production, as well as potential use in different applications. LOXs may fulfill an important role in the design of processes that are far more environmental friendly than currently used chemical reactions. Difficulties in screening for the optimal enzymes and producing LOX enzymes in sufficient amounts prevent large-scale application so far. With this review, we summarize current knowledge of LOX enzymes and the way in which they can be produced and applied.
publisher TAYLOR & FRANCIS LTD
issn 0738-8551
year published 2016
volume 36
issue 4
beginning page 665
ending page 674
digital object identifier (doi) 10.3109/07388551.2015.1004520
web of science category Biotechnology & Applied Microbiology
subject category Biotechnology & Applied Microbiology
unique article identifier WOS:000381053900008
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journal analysis (jcr 2019):
journal impact factor 8.108
5 year journal impact factor 7.55
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