authors |
Brandts, I; Teles, M; Tvarijonaviciute, A; Pereira, ML; Martins, MA; Tort, L; Oliveira, M |
nationality |
International |
journal |
GENOMICS |
author keywords |
Nanoplastics; Sea bass; Lipid metabolism; Gene expression |
keywords |
POLYSTYRENE NANOPARTICLES; SKIN MUCUS; STRESS; MICROPLASTICS; METABOLISM; EXPRESSION; ENVIRONMENT; TOXICITY; TISSUE; GENES |
abstract |
The present study aimed to evaluate the effects of similar to 45 nm nanoplastics (NPs) on the marine fish Dicentrarchus labrax after a short-term exposure. Animals were exposed to a concentration range of NPs for 96 h and liver, plasma and skin mucus were sampled. Assessed endpoints included biochemical biomarkers and expression of genes related to lipid metabolism, immune system and general cell stress. Abundance of mRNA transcripts related to lipid metabolism, ppara and ppary, were significantly increased after exposure to NPs. Biochemical endpoints revealed decreased esterase activity levels in plasma, suggesting that the immune system of fish might be compromised by exposure to NPs. Moreover, significantly lower levels of alkaline phosphatase were found in the skin mucus of animals exposed to NPs. The present results suggest that NPs may represent a hazard to this marine fish, potentially interfering with the metabolism of lipids and the correct function of the immune response. |
publisher |
ACADEMIC PRESS INC ELSEVIER SCIENCE |
issn |
0888-7543 |
year published |
2018 |
volume |
110 |
issue |
6 |
beginning page |
435 |
ending page |
441 |
digital object identifier (doi) |
10.1016/j.ygeno.2018.10.006 |
web of science category |
Biotechnology & Applied Microbiology; Genetics & Heredity |
subject category |
Biotechnology & Applied Microbiology; Genetics & Heredity |
unique article identifier |
WOS:000451057100014
|