abstract
This work aims at extending the applicability of chiral aqueous biphasic systems (ABS) to enantioseparations by using chiral ionic liquids (CILs) simultaneously as phase forming agents and chiral selectors. After determining the ternary phase diagrams of ABS composed of CILs and salts, these were used to ascertain the CIL structure on the ABS aptitude to separate mandelic acid enantiomers. Representative CIL-based ABS were further employed in optimization studies, where the mandelic acid content, temperature, tie-line length (TLL), salt and phases weight ratio were studied. The influence of these parameters is shown to be highly dependent on the CIL-based ABS, however the results here reported suggest that the key driving the enantioseparation in these ABS is a combination of the enantiorecognition ability of a given CIL with the solubility of mandelic acid in the corresponding CIL-rich phase.
keywords
2-PHASE SYSTEMS; PHENYLSUCCINIC ACID; ENANTIOSELECTIVE EXTRACTION; BETA-CYCLODEXTRIN; AMINO-ACIDS; SEPARATION; RESOLUTION; RECOGNITION; PHENYLALANINE; SOLVENT
subject category
Chemistry
authors
Silva, FAE; Kholany, M; Sintra, TE; Caban, M; Stepnowski, P; Ventura, SPM; Coutinho, JAP
our authors
Ana Francisca Osório de Almeida Coelho e Silva
Junior Researcher
Mariam Kholany
Collaborator
Sónia Patrícia Marques Ventura
Assistant Professor
Tânia Ereira Sintra
Post-Doc FellowshipGroups
G4 - Renewable Materials and Circular Economy
G5 - Biomimetic, Biological and Living Materials
Projects
CICECO - Aveiro Institute of Materials (UID/CTM/50011/2013)
Projeto de Investigação Exploratória: Sónia Patricia Marques Ventura (IF/00402/2015)
acknowledgements
Separação de fármacos quirais por cromatografia de partição centrífuga usando sistemas aquosos bifásicos enantioseletivos. ChiResus