Aqueous Biphasic Systems Using Chiral Ionic Liquids for the Enantioseparation of Mandelic Acid Enantiomers

authors	Silva, FAE; Kholany, M; Sintra, TE; Caban, M; Stepnowski, P; Ventura, SPM; Coutinho, JAP
nationality	International
journal	SOLVENT EXTRACTION AND ION EXCHANGE
author keywords	Aqueous biphasic systems; chiral ionic liquids; enantioseparation; mandelic acid enantiomers; enantiomeric excess
keywords	2-PHASE SYSTEMS; PHENYLSUCCINIC ACID; ENANTIOSELECTIVE EXTRACTION; BETA-CYCLODEXTRIN; AMINO-ACIDS; SEPARATION; RESOLUTION; RECOGNITION; PHENYLALANINE; SOLVENT
abstract	This work aims at extending the applicability of chiral aqueous biphasic systems (ABS) to enantioseparations by using chiral ionic liquids (CILs) simultaneously as phase forming agents and chiral selectors. After determining the ternary phase diagrams of ABS composed of CILs and salts, these were used to ascertain the CIL structure on the ABS aptitude to separate mandelic acid enantiomers. Representative CIL-based ABS were further employed in optimization studies, where the mandelic acid content, temperature, tie-line length (TLL), salt and phases weight ratio were studied. The influence of these parameters is shown to be highly dependent on the CIL-based ABS, however the results here reported suggest that the key driving the enantioseparation in these ABS is a combination of the enantiorecognition ability of a given CIL with the solubility of mandelic acid in the corresponding CIL-rich phase.
publisher	TAYLOR & FRANCIS INC
issn	0736-6299
year published	2018
volume	36
issue	6
beginning page	617
ending page	631
digital object identifier (doi)	10.1080/07366299.2018.1545344
web of science category	Chemistry, Multidisciplinary
subject category	Chemistry
unique article identifier	WOS:000457723000008