Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

abstract

The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. ThreelLs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of Its in BC led to translucent and homogeneous membranes stable up to 190 degrees C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-as were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications. (C) 2020 Elsevier B.V. All rights reserved.

keywords

CELLULOSE MEMBRANES; BIOCELLULOSE MEMBRANES; TRANSDERMAL DELIVERY; RELEASE; HYDROCHLORIDE; ACIDS

subject category

Chemistry; Physics

authors

Chantereau, G; Sharma, M; Abednejad, A; Vilela, C; Costa, EM; Veiga, M; Antunes, F; Pintado, MM; Sebe, G; Coma, V; Freire, MG; Freire, CSR; Silvestre, AJD

Groups

G4 - Renewable Materials and Circular Economy
G5 - Biomimetic, Biological and Living Materials

Projects

CICECO - Aveiro Institute of Materials (UID/CTM/50011/2019)

EJD-FUNMAT - European Joint Doctorate in Functional Materials Research (EJD-FUNMAT)

Rede Nacional de Ressonância Magnética Nuclear (PTNMR)

acknowledgements

This work was developed within the scope of project CICECO-Aveiro Institute of Materials (FCT Ref. UID/CTM/50011/2019), financed by national funds through the FCT/MEC. G. Chantereau thanks the European Joint Doctorate in Functional Materials Research EJD FunMat (Grant agreement ID: 641640) for the PhD fellowship. Laboratoire de Chimie des Polymeres Organiques (LCPO, CNRS UMR 5629) is also acknowledged. The research contract of C. Vilela is funded by national funds (OE), through FCT -Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23, of the Decree -Law 57/2016, of August 29, changed by Law 57/2017, of July 19. FCT is also acknowledged for the research contract under Stimulus of Scientific Employment 2017 to C.S.R. Freire (CEECIND/00464/2017). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).