authors |
Chantereau, G; Sharma, M; Abednejad, A; Vilela, C; Costa, EM; Veiga, M; Antunes, F; Pintado, MM; Sebe, G; Coma, V; Freire, MG; Freire, CSR; Silvestre, AJD |
nationality |
International |
journal |
JOURNAL OF MOLECULAR LIQUIDS |
author keywords |
Bacterial nanocellulose; Vitamin B; Ionic liquids; Cholinium-based ILs; Skin care applications; Antioxidant activity |
keywords |
CELLULOSE MEMBRANES; BIOCELLULOSE MEMBRANES; TRANSDERMAL DELIVERY; RELEASE; HYDROCHLORIDE; ACIDS |
abstract |
The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. ThreelLs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of Its in BC led to translucent and homogeneous membranes stable up to 190 degrees C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-as were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications. (C) 2020 Elsevier B.V. All rights reserved. |
publisher |
ELSEVIER |
issn |
0167-7322 |
isbn |
1873-3166 |
year published |
2020 |
volume |
302 |
digital object identifier (doi) |
10.1016/j.molliq.2020.112547 |
web of science category |
Chemistry, Physical; Physics, Atomic, Molecular & Chemical |
subject category |
Chemistry; Physics |
unique article identifier |
WOS:000518870300063
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
5.065 |
5 year journal impact factor |
4.766 |
category normalized journal impact factor percentile |
81.277 |
dimensions (citation analysis):
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altmetrics (social interaction):
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