Unveiling the mechanism of hydrotropy: evidence for water-mediated aggregation of hydrotropes around the solute


A recent proposal attributes the origin of hydrotropy to the water-mediated aggregation of hydrotrope molecules around the solute. Experimental evidence for this phenomenon is reported for the first time in this work, using(1)H-NMR. A new computational technique to quantify apolarity is introduced and is used to show that apolarity of both solute and hydrotrope is the driving force of hydrotropy.



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Abranches, DO; Benfica, J; Soares, BP; Leal-Duaso, A; Sintra, TE; Pires, E; Pinho, SP; Shimizu, S; Coutinho, JAP

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This work was developed within the scope of the projects CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, and CIMO-Mountain Research Center, UIDB/00690/2020, both financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project No. 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Financial support from Ministerio de Ciencia, Innovacion (project RTI2018-093431-B-I00) and the Gobierno de Aragon (Group E37_17R) co-funded by FEDER 2014-2020 Construyendo Europa desde Aragon'' is acknowledged. B. P. S. acknowledges FCT for her PhD grant SFRH/BD/138439/2018.

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