Polysaccharide Structures and Their Hypocholesterolemic Potential
authors Silva, IMV; Machado, F; Moreno, MJ; Nunes, C; Coimbra, MA; Coreta-Gomes, F
nationality International
journal MOLECULES
author keywords polysaccharides; chitosan; beta-glucans; cholesterol homeostasis; viscosity; bile salt sequestration; microbiota; hypocholesterolemic ingredients; fiber
keywords BILE-ACID-BINDING; PLANTAGO-OVATA-FORSK; PHYSICAL-CHEMICAL BEHAVIOR; IN-VITRO FERMENTATION; CHAIN FATTY-ACIDS; GUAR GUM; DIETARY-FIBERS; PHYSICOCHEMICAL PROPERTIES; SULFATED POLYSACCHARIDES; CHOLESTEROL ABSORPTION
abstract Several classes of polysaccharides have been described to have hypocholesterolemic potential, namely cholesterol bioaccessibility and bioavailability. This review will highlight the main mechanisms by which polysaccharides are known to affect cholesterol homeostasis at the intestine, namely the effect (i) of polysaccharide viscosity and its influence on cholesterol bioaccessibility; (ii) on bile salt sequestration and its dependence on the structural diversity of polysaccharides; (iii) of bio-transformations of polysaccharides and bile salts by the gut microbiota. Different quantitative structure-hypocholesterolemic activity relationships have been explored depending on the mechanism involved, and these were based on polysaccharide physicochemical properties, such as sugar composition and ramification degree, linkage type, size/molecular weight, and charge. The information gathered will support the rationalization of polysaccharides' effect on cholesterol homeostasis and highlight predictive rules towards the development of customized hypocholesterolemic functional food.
publisher MDPI
isbn 1420-3049
year published 2021
volume 26
issue 15
digital object identifier (doi) 10.3390/molecules26154559
web of science category 17
subject category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
unique article identifier WOS:000682289900001
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.267
5 year journal impact factor 3.589
category normalized journal impact factor percentile 56.714
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