Scaffolds for bone restoration from cuttlefish
authors Rocha, JHG; Lemos, AF; Agathopoulos, S; Valerio, P; Kannan, S; Oktar, FN; Ferreira, JMF
nationality International
journal BONE
author keywords scaffolds; cuttlefish bone; hydroxyapatite; biocompatibility; bioactivity
keywords OSTEOBLAST-LIKE CELLS; BIOACTIVE GLASSES; HYDROXYAPATITE; PROLIFERATION; BIOCERAMICS; TEMPERATURE; COMPOSITES; CULTURE; SYSTEM
abstract Scaffolds of pure hydroxyapatite suitable for either direct clinical use or tissue-engineering applications were successfully produced via hydrothermal transformation of aragonite, obtained from fresh cuttlefish bones, at 200 degrees C followed by sintering. Beyond low production cost, worldwide availability and natural-biological origin of raw materials, the produced scaffolds have ideal pore size and interconnectivity features suitable for supporting biological activities, such as bone tissue growth and vascularization. Bioactivity in vitro tests were excellent: (a) rapid and pronounced formation of hydroxyapatite occurred when the scaffolds were immersed in simulated body fluid (SBF), and (b) outstanding proliferation of osteoblasts was registered. The produced scaffolds can be machined and shaped very easily at any stage of processing. Therefore, these ceramic scaffolds can satisfy both bioactivity demands and the requirements for shaping of tailor-made individualized implants, especially for randomly damaged bones. (c) 2005 Elsevier Inc. All rights reserved.
publisher ELSEVIER SCIENCE INC
issn 8756-3282
year published 2005
volume 37
issue 6
beginning page 850
ending page 857
digital object identifier (doi) 10.1016/j.bone.2005.06.018
web of science category Endocrinology & Metabolism
subject category Endocrinology & Metabolism
unique article identifier WOS:000234340700014
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journal analysis (jcr 2019):
journal impact factor 4.147
5 year journal impact factor 4.349
category normalized journal impact factor percentile 75.175
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