Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data

abstract

A series of the most common chelators used in magnetic resonance imaging ( MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X- ray structures and theoretical studies.

keywords

ALKALINE-EARTH-METAL; X-RAY CRYSTAL; BEARING BENZYLPHOSPHINATE GROUPS; NUCLEAR-MAGNETIC-RESONANCE; MACROCYCLIC LIGAND DOTA; WATER EXCHANGE-RATE; IN-VIVO BEHAVIOR; LANTHANIDE COMPLEXES; 1,4,8,11-TETRAAZACYCLOTETRADECANE-1,4,8,11-TETRAACETIC ACID; MOLECULAR-STRUCTURE

subject category

Chemistry

authors

Delgado, R; Felix, V; Lima, LMP; Price, DW

our authors

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