H-1 NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal
authors Lehtonen, HM; Lindstedt, A; Jarvinen, R; Sinkkonen, J; Graca, G; Viitanen, M; Kallio, H; Gil, AM
nationality International
journal FOOD CHEMISTRY
author keywords Lingonberry; NMR; Nutritional metabolomics; Polyphenol ingestion; Postprandial state; Urine metabolites
keywords PLASMA ASYMMETRIC DIMETHYLARGININE; FRUIT ACIDS; POLYPHENOLS; HUMANS; JUICE; EXCRETION; CRANBERRY; SUGARS
abstract The use of NMR metabolomics in clinical trials is growing; however, reports of postprandial experiments in humans are scarce. The present study investigated whether consumption of lingonberries as a supplement to an oil-rich meal modifies the postprandial fingerprints of human urine. Urine samples were analysed by H-1 NMR, and untargeted multivariate analysis was applied to the data for comprehensive fingerprinting. A clear separation of postprandial lingonberry meal samples was revealed. To evaluate statistical differences, a targeted approach was applied for the informative spectral areas. Significantly (p < 0.05) increased levels of polyphenol metabolites, hippuric acid and 4-hydroxyhippuric acid, and decreased creatinine and dimethylamine levels were the major explanations for the grouping of the postprandial samples after the different meals. Thus, inclusion of polyphenol-rich lingonberry powder in a rapeseed oil-rich meal modifies the metabolic profile of urine which may be used to reveal both consumption of berries and health-promoting changes in the common metabolism. (C) 2012 Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0308-8146
year published 2013
volume 138
issue 2-3
beginning page 982
ending page 990
digital object identifier (doi) 10.1016/j.foodchem.2012.10.081
web of science category Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
subject category Chemistry; Food Science & Technology; Nutrition & Dietetics
unique article identifier WOS:000316039500037
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