Adsorption mechanism of 5-flourouracil on different hydroxyapatite particles

authors	Santos, C; Martins, MA; Almeida, MM; Costa, MEV
editors	Vilarinho, PM
nationality	International
journal	ADVANCED MATERIALS FORUM III, PTS 1 AND 2
author keywords	hydroxyapatite; adsorption; drug delivery; 5-Flourouracil
keywords	IN-VITRO; RELEASE; 5-FLUOROURACIL; CISPLATIN
abstract	The adsorption of the drug 5-Flourouracil (5-FU) on Hydroxyapatite (HAP) particles having different surface conditions is studied at 37 degrees C. Commercial HAP particles, either as received or soaked in citrate solutions are used as drug adsorbents and compared to a third category of HAP particles which consists of granules obtained by spray drying suspensions of HAP nanoparticles previously precipitated in citrate solutions. The adsorbed amount of 5-FU on the HAP particles surface is conditioned by the existing pre-adsorbed citrate ions which contribute to modify the particle surface charge and thus decrease the drug adsorption. However the obtained results also demonstrate that the particle surface charge is not the unique factor to govern the 5-FU adsorption on the HAP particles surface.
publisher	TRANS TECH PUBLICATIONS LTD
issn	0255-5476
year published	2006
volume	514-516
beginning page	1103
ending page	1107
web of science category	Materials Science, Multidisciplinary
subject category	Materials Science
unique article identifier	WOS:000238056400220