Maria Margarida Tavares Lopes Almeida

Emeritus Professor

Short CV

Academic degrees:

   - Graduation in Chemical Engineering, IST, Technical University of Lisbon

   - PhD in Materials Science and Engineering, University of Aveiro, Jan 1988

 

Scientific Interests

-Chemical synthesis of nano and micro-sized calcium phosphate particles for biomedical applications;

- Preparation and characterization of porous scaffolds (polymer/ceramic composites) for biomedical applications;

- Drug releasing systems and composite scaffolds for regenerative medicine and tissue engineering.

Selected Publications

Santos C, Gomes PS, Duarte JA, Franke RP, Almeida MM, Costa MEV, Fernandes MH (2012) “ Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response”, J.R.Soc.Interface, Vol 9 / nº 7, 3397-3410

Petrauskaite O, Liesiene J, Santos C, Gomes PS,  Garcia M,  Fernandes MH, Almeida MM, Costa MEV, Juodzbalys G, Daugela P,  Nano-Hydroxyapatite/Cellulose composite scaffold for bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 6, (2012) 34-34.

Computational study of hydroxyapatite properties and surface interactions, A V.Bystrov, E.Costa, C.Santos, M.M.Almeida, A.Kholkin, S.Kopyl, YDekhtyar, A.V.Bystrova, E.V.Paramonova, Proc. of Joint Symposium  ISAF/ECAPD/PFM 2012, pp 1-3

Endres S, Hiebl B, Hagele J, Beltzer C, Fuhrmann R, Jager V, Almeida M, Costa E, Santos C Traupe H, Jung EM, Prantl L, Wilke A, Franke RP (2011)  "Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells”, Clinical Hemorheology and Microcirculation, 48, 29-40.

C.Santos, M. M Almeida, M.E.V. Costa , “Synthesis and characterization of amino-acid funcionalized hydroxyapatite nanoparticles” Cells and Materials, 2010, 20, 3, 223-223

C.Santos, M.A. Martins, M.M. Almeida and M.E.V. Costa, Influence of the (citric acid/ calcium) ratio on hap particles synthesis, Microscopy and Microanalysis, 15 (2009)85-86

- C.Santos, M.A. Martins, R.-P. Franke, M.M. Almeida, M.E.V. Costa, " Calcium phosphate granules for use as a 5-Fluorouracil delivery system", Ceramics International, 35 (2009) 1587-1594

C.Santos, C.F. Rovath, R.-P. Franke, M.M. Almeida, M.E.V. Costa, " Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system", Ceramics International, 35(2009)509-513

- T. Scharnweber, J. Fink, R. Fuhrmann, C. Santos, M.M. Almeida, M.E.V. Costa, R.-P. Franke, “Tissue engineering with calcium phosphate composite scaffolds”, Clinical Hemorheology and Microcirculation, 2009, 42, 169

- B. Hiebl, R. Fuhrmann, M.E.V. Costa, M.M. Almeida, R.P. Franke, "In vitro 3D assay to test angiogenic effects of human CD 14+ monocytes seeded on macroporous PLGA/CaP polymers with a CaP nanostructured surface", Clinical Hemorheology and Microcirculation, 40(1) (2008) 37-50

- Tim Scharnweber, Catarina Santos, Ralf-Peter Franke, Maria Margarida Almeida and Maria Elisabete Veira Costa, "Influence of spray-dried hydroxyapatite-5-Fluorouracil granules on cell lines derived from tissues of mesenchymal origin”, Molecules 13, (2008) 2729-2739

- C.Santos, R.-P. Franke, M.M. Almeida and M.E.V. Costa, “Nanoscale Characterization of Hydroxyapatite Particles by Electron Microscopy”, Microscopy and Microanalysis,14(2008)67-70

- M A. Martins, C. Santos, M. M. Almeida, M. E. V. Costa, “Hydroxyapatite micro- and nano-particles: nucleation and growth mechanisms in the presence of citrate species”,Journal of Colloids and Interface Science, (2008), 318, 2, 210-216.

- C.Santos, R.-P. Franke, M.M. Almeida, M.E.V. Costa and M.H. Fernandes “Viability and proliferation of MG-63 osteoblastic cells exposed to hydroxyapatite nanoparticles with different characteristics”, Tissue Engineering Part A, (2008), 14, 5, 810-810.

- R.-P. Franke, M.M. Almeida, M.E.V. Costa, C. Santos, V. Jaeger; A. Wike; R. Fuhrman, “Bridging Critical size defects applying tissue engineering”, Tissue Engineering Part A, (2008),14, 5, 816-816.

R.-P. Franke, C. Santos, T Scharnweber, M. M. Almeida and M. E. V. Costa, “Influence of nanostructured calcium-phosphate particles on rat osteosarcoma cells”, Basic & Clinical Pharmacology & toxicology, (2007), 101, 5, 360-360.

 

Ongoing Supervisions

Projects

Cellular oxide catalysts for emission lean combustion in porous media (LEANCOMB)

PartnerFundação para a Ciência e a Tecnologia
cellular ceramics, combustion, catalysts, functionalization

Desenvolvimento de novas peças em grés com maior valor acrescentado através de processos mais sustentáveis (M2GRES2)

PartnerIndustry National

Long Lasting reinforced Concrete for Energy Infrastructure under Severe Operating (LORCENIS)

PartnerEuropean Comission
The main goal of the LORCENIS project is to develop long reinforced concrete for energy infrastructures with lifetime extended up to a 100% under extreme operating conditions. The concept is based on an optimal combinationof novel technologies involving customized methodologies for cost-efficient operation. 4 scenarios of severe oper...

M2GRÉS - Grés utilitário de elevado desempenhoao nivel do metal-marking, a custo reduzido e em monocozedura (M2GRÉS)

PartnerIndustry National
O projeto M2Grés - Grés utilitário de elevado desempenho ao nível do metal-marking, a custo reduzido e em monocozedura?, promovido pelo consórcio constituído pela empresa Ria Stone e pelo Centro de Investigação em Materiais Cerâmicos e Compósitos da Universidade de Aveiro (CICECO) tem como objetivo o desenvolvimento de uma nova linha de peças em...

NEWGEN - New Generation Biomimetic and Customized Implants for Bone Engineering (NEWGEN)

PartnerEuropean Comission
This COST Action, NEWGEN, aims at creating the seed for the European research and industry collaboration, combining basic knowledge from academic laboratories, R&D centres, medical units from hospitals, and a significant number of companies.With a predicted ageing population and increasing expectations regarding quality o...

Stainless steel coating of WC particles by sputtering (POCTI/CTM/35460/1999)

PartnerFundação para a Ciência e a Tecnologia
powder coating composites sputtering tungsten carbide

TISSUE REACTOR - Development of a Bioreactor-Based Connective Tissue Production Line (TISSUE REACTOR)

Local CoordinatorEuropean Comission
It is the aim of this project to engineer connective tissue in vitro and to demonstrate its applicability as a tissue substitute in vivo. To achieve this goal a continuous cultivation process based on a perfused fixed-bed bioreactor system and its components will be developed which allows the production of large quantities of three-dimensional (...

Publications

Purification of anthocyanins from grape pomace by centrifugal partition chromatography

Lima, AS; de Oliveira, BS; Shabudin, SV; Almeida, M; Freire, MG; Bica, K
2021, JOURNAL OF MOLECULAR LIQUIDS, 326.
ISBN: 1873-3166

Glutaraldehyde-crosslinking chitosan scaffolds reinforced with calcium phosphate spray-dried granules for bone tissue applications

Pinto, RV; Gomes, PS; Fernandes, MH; Costa, MEV; Almeida, MM
2020, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 109.
ISBN: 1873-0191

Effect of Fe2O3 doping on colour and mechanical properties of Y-TZP ceramics

Holz, L; Macias, J; Vitorino, N; Fernandes, AJS; Costa, FM; Almeida, MM
2018, CERAMICS INTERNATIONAL, 44, 15, 17962-17971.

Development and characterization of zirconia-alumina composites for orthopedic implants

Sequeira, S; Fernandes, MH; Neves, N; Almeida, MM
2017, CERAMICS INTERNATIONAL, 43, 1, 693-703.
ISBN: 1873-3956

Development of hydroxyapatite nanoparticles loaded with folic acid to induce osteoblastic differentiation

Santos, C; Gomes, P; Duarte, JA; Almeida, MM; Costa, MEV; Fernandes, MH
2017, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 516, 01-Feb, 185-195.
ISBN: 1873-3476

Recycling liquid effluents in a ceramic industry

de Almeida, BA; Almeida, M; Martins, S; Macarico, VA; da Fonseca, AT
2016, BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO, 55, 3, 95-104.

Morphological Evolution of Hydroxyapatite Particles in the Presence of Different Citrate:Calcium Ratios

Santos, C; Almeida, MM; Costa, ME
2015, CRYSTAL GROWTH & DESIGN, 15, 9, 4417-4426.

Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

dos Santos, CF; Gomes, PS; Almeida, MM; Willinger, MG; Franke, RP; Fernandes, MH; Costa, ME
2015, RSC ADVANCES, 5, 85, 69184-69195.

Complex Effect of Hydroxyapatite Nanoparticles on the Differentiation and Functional Activity of Human Pre-Osteoclastic Cells

Costa-Rodrigues, J; Silva, A; Santos, C; Almeida, MM; Costa, ME; Fernandes, MH
2014, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 10, 12, 3590-3600.

A Computational Study of the Properties and Surface Interactions of Hydroxyapatite

Bystrov, VS; Paramonova, EV; Costa, MEV; Santos, C; Almeida, M; Kopyl, S; Dekhtyar, Y; Bystrova, AV; Maevsky, EI; Pullar, RC; Kholkin, AL
2013, FERROELECTRICS, 449, 1, 94-101.

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