New PMMA-co-EHA glass-filled composites for biomedical applications: Mechanical properties and bioactivity
authors Lopes, P; Corbellini, M; Ferreira, BL; Almeida, N; Fredel, M; Fernandes, MH; Correia, R
nationality International
journal ACTA BIOMATERIALIA
author keywords Acrylic bone cements; Glass filler; Mechanical properties; Bioactivity
keywords ACRYLIC BONE-CEMENT; IN-VITRO BIOACTIVITY; FUNCTIONALIZED METHACRYLATES; HYDROXYAPATITE; PARTICLES; APATITE; HA
abstract A bioactive glass of the 3CaO center dot P(2)O(5)-MgO-SiO(2) System was incorporated as a filler into poly(methylmethacrylate)-co-(ethylhexylacrylate) (PMMA-co-EHA) copolymer. The effect of filler proportion (0, 30, 40 and 50 wt.%) on the bending properties was evaluated and a maximum flexural strength of 29 MPa coupled with an elastic modulus of 1.1 GPa was obtained at an intermediate filler concentration (30 wt.%). These values are slightly higher than those usually reported for human cancellous bone. The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF, Kokubo solution). Inductively coupled plasma was used to trace the evolution of ionic concentrations in the SBF solution, namely Ca and P. X-ray diffraction and scanning electron microscopy confirmed the growth of spherical calcium phosphate aggregates on the surface of composites, indicating that the composites are potentially bioactive. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 1742-7061
year published 2009
volume 5
issue 1
beginning page 356
ending page 362
digital object identifier (doi) 10.1016/j.actbio.2008.07.012
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000261922400037
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journal impact factor 7.242
5 year journal impact factor 7.502
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