resumo
The complexes [(eta(5)-C5H4-CO-R)Mo(CO)(2)(eta(3)-C3H5)] [R = OH (1), Phe OMe (2)] have been examined as guests for the cyclodextrin (CD) hosts beta-CD and heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, C-13{H-1) cross-polarisation (CP) magic angle spinning (MAS) NM R spectroscopy and ITTIR spectroscopy. Singlecrystal X-ray analysis of 1 shows that the unit cell contains centrosymmetric supramolecular dimers comprising two di- carlx)nyl complexes linked through hydrogen-bonding interactions involving the carboxylic acid groups. In screening tests for antiproliferative effects, the Cl) adducts containing 1 displayed enhanced antitumour activity against mouse melanoma (when compared with nonincluded 1), while showing minimal activity towards human adenocarcinoma and nontumour rat myoblast cell lines. TRIMEB encapsulation resulted in a predominant toxic effect on tumour cells versus the rion-neoplastic rriyoblasl cells.
palavras-chave
ORGANOMETALLIC CONFORMATIONAL EQUILIBRIA; CAMBRIDGE STRUCTURAL DATABASE; RING INDENYL ANALOGS; BETA-CYCLODEXTRIN; CRYSTAL-STRUCTURES; ALLYL COMPLEXES; MIXED-RING; MOLYBDENUM COMPLEXES; CATALYST PRECURSORS; TUNGSTEN COMPLEXES
categoria
Chemistry
autores
Braga, SS; Mokal, V; Paz, FAA; Pillinger, M; Branco, AF; Sardao, VA; Diogo, CV; Oliveira, PJ; Marques, MPM; Romao, CC; Goncalves, IS
nossos autores
Filipe Alexandre Almeida Paz
Investigador Principal
Isabel Maria de Sousa Gonçalves
Professor associado
Martyn Pillinger
Investigador Júnior
Susana Isabel Fonseca de Almeida Santos Braga
InvestigadorProjectos
Use of molecular containers to modify metallocene-based catalysts (PTDC/QEQ-SUP/1906/2012)
agradecimentos
This work was partly financed by the Fundo Europeu de Desenvolvimento Regional (FEDER) through COMPETE (Programa Operacional Factores de Competitividade) and by Portuguese national funds through the Fundacao para a Ciencia e a Tecnologia FCT) within the projects PEst-OE/QUI/UI0070/2011, CICECO - FCOMP-01-0124-FEDER-037271 (FCT ref. PEst-C/CTM/LA0011/2013), QOPNA - FCOMP-01-0124-FEDER-037296 (PEst C-QUI/UI0062/2013) and FCOMP-01-0124-FEDER-029779 (FCT ref. PTDC/QEQ-SUP/1906/2012). The authors further wish to thank FCT for specific funding towards the purchase of the single-crystal diffractometer.